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Related Experiment Video

Updated: Feb 13, 2026

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Published on: November 7, 2013

Recent developments in intracellular protein delivery.

Yumiao Zhang¹, Joachim Justad Røise², Kunwoo Lee³

¹Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA.

Current Opinion in Biotechnology

|February 28, 2018

Summary

This summary is machine-generated.

Developing protein therapeutics for untreatable diseases faces delivery challenges. This review explores advances in intracellular protein delivery for vaccines, gene editing, and cancer therapies, offering hope for new cures.

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Last Updated: Feb 13, 2026

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

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Published on: November 7, 2013

Development and Assessment of Intracellular Infection Models for Staphylococcus aureus

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Published on: January 17, 2025

Biotinylated Cell-penetrating Peptides to Study Intracellular Protein-protein Interactions

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Published on: December 20, 2017

Area of Science:

Biotechnology
Molecular Medicine
Drug Delivery

Background:

Protein therapeutics offer potential cures for numerous diseases.
Cytoplasmic delivery of protein therapeutics is a significant hurdle.
Intracellular delivery strategies are crucial for therapeutic efficacy.

Purpose of the Study:

To review recent advancements in intracellular protein therapeutics.
To highlight strategies enabling protein entry into the cytoplasm.
To discuss the therapeutic potential of these advances.

Main Methods:

Literature review of intracellular protein therapeutics.
Focus on four key therapeutic classes: vaccines, transcription factors, gene editing, and cancer therapies.
Analysis of progress and challenges in protein delivery.

Main Results:

Significant progress has been made in developing strategies for intracellular protein delivery.
Four main classes of intracellular protein therapeutics show promise.
These advances are paving the way for potential cures.

Conclusions:

Overcoming cytoplasmic delivery challenges is key to realizing the potential of protein therapeutics.
Intracellular protein therapeutics represent a promising frontier for treating currently untreatable diseases.
Continued research in this area may lead to transformative medical treatments.