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New lignan glycosides from Cissus quadrangularis stems.

Padam Kumar1, Kapil Dev1,2, Khushbu Sharma1,3

  • 1a Medicinal and Process Chemistry Division , CSIR- Central Drug Research Institute , Lucknow , India.

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|March 1, 2018
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Summary

This study isolated new compounds from Cissus quadrangularis stems, including phenolic and lignan glycosides. These findings expand the known phytochemical profile of the Cissus genus.

Keywords:
Vitaceaelignanslignans glycosidesmegastigmane glycosidesphenolic glycosidessesquiterpenes

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Area of Science:

  • Natural Product Chemistry
  • Phytochemistry
  • Organic Chemistry

Background:

  • Cissus quadrangularis is a plant with a rich history of traditional medicinal use.
  • The phytochemical diversity of the Cissus genus remains an active area of research.

Purpose of the Study:

  • To conduct a detailed phytochemical investigation of Cissus quadrangularis stems.
  • To isolate and characterize novel and known compounds from this plant species.

Main Methods:

  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation employing comprehensive spectroscopic analyses, including 1D and 2D NMR and mass spectrometry.

Main Results:

  • One new phenolic glycoside and two new lignan glycosides were successfully isolated.
  • Twelve known compounds were identified, with several being reported for the first time in the Cissus genus or this specific plant.

Conclusions:

  • The phytochemical analysis of Cissus quadrangularis stems has yielded significant new chemical entities.
  • This research contributes to the understanding of the chemical constituents of Cissus quadrangularis and the broader Cissus genus.