[Common variable immune deficiency in adults: focus on pulmonary complications]

Area of Science:

• Immunology
• Pulmonology
• Clinical Medicine

Background:

• Common variable immune deficiency (CVID) is the most frequent primary immunodeficiency in adults.
• Pulmonary complications are a leading cause of morbidity and mortality in CVID patients.
• Recurrent bronchopulmonary inflammatory diseases significantly impact CVID patient survival and quality of life.

Purpose of the Study:

• To highlight the critical importance of timely diagnosis in managing CVID.
• To raise awareness among healthcare professionals regarding CVID and its pulmonary manifestations.
• To emphasize the need for multidisciplinary collaboration to prevent irreversible complications.

Main Methods:

• Case study presentation of two adult patients with CVID.
• Review of diagnostic pathways and treatment challenges.
• Analysis of factors contributing to diagnostic delays.

Main Results:

• Both cases illustrate significant delays in CVID diagnosis.
• Delayed diagnosis led to the development of severe, irreversible pulmonary damage.
• The presented cases underscore the impact of delayed diagnosis on patient prognosis.

Conclusions:

• Prompt diagnosis of CVID is essential for effective management.
• Increased awareness and interdisciplinary communication can reduce diagnostic delays.
• Timely intervention can mitigate the severity of pulmonary complications in CVID.