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Assessment of Specific IgE Levels to Major Allergens Fel d 1 and Can f 1 Using the AllergochipRF and ImmunoCAP
E M Kozlov1, D R Trifonova1, K A Riabova1
1I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Abstract:
We assessed specific IgE levels to the major epidermal allergens of cat (Fel d 1) and dog (Can f 1) in 55 patients with clinically confirmed sensitization, using both the experimental microchip-based platform AllergochipRF and the reference ImmunoCAP system. A high degree of agreement was observed between the two platforms, with Spearman correlation coefficients of r = 0.94 for Fel d 1 and r = 0.85 for Can f 1 (p < 0.001). Differences in absolute specific IgE values were noted, which can be attributed to the distinct analytical principles of the platforms, particularly the upper measurement limit of ImmunoCAP and the broader dynamic signal range of AllergochipRF. These findings confirm the analytical comparability of the two methods and highlight the potential of AllergochipRF for expanded molecular diagnosis of sensitization and for monitoring the efficacy of allergen-specific immunotherapy.
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