[Safety of fluoroquinolones: risks usually forgotten for the clinician]

Area of Science:

• Pharmacology
• Clinical Medicine
• Drug Safety

Background:

• Quinolones are broad-spectrum antimicrobials frequently prescribed for various infections.
• While generally considered safe, understanding their adverse event profile is crucial for healthcare providers.
• Potential risks necessitate vigilant monitoring to ensure patient safety.

Purpose of the Study:

• To review and highlight the key safety concerns associated with quinolone antimicrobial agents.
• To inform healthcare professionals about the spectrum of potential adverse effects.
• To emphasize the importance of monitoring specific patient populations.

Main Methods:

• Literature review of reported adverse events associated with quinolone use.
• Analysis of safety data focusing on musculoskeletal, endocrine, cardiovascular, and nervous system effects.
• Consideration of drug interactions and special populations, including children.

Main Results:

• Musculoskeletal risks include cartilage damage and tendon rupture.
• Endocrine effects involve potential glucose level disturbances (hypoglycemia/hyperglycemia), requiring monitoring in diabetics.
• Cardiovascular and nervous system adverse events, such as arrhythmias and neuropathy, can occur.

Conclusions:

• Quinolone therapy requires careful monitoring for potential adverse effects across multiple organ systems.
• Special attention should be paid to diabetic patients and children, despite emerging evidence suggesting potentially lower risks in pediatric cases.
• Comprehensive safety evaluation is paramount for all patients receiving quinolone treatment.