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Lower Serum Irisin Levels Are Associated with Increased Vascular Calcification in Hemodialysis Patients

Lian He, Wan-Yu He, La-Ta A

    Kidney & Blood Pressure Research
    |March 1, 2018
    PubMed

    Insights

    Lower serum irisin levels are linked to vascular calcification in hemodialysis patients. This finding highlights irisin as a potential biomarker for cardiovascular risk in this population.

    Area of Science:

    • Nephrology
    • Cardiovascular Medicine
    • Endocrinology

    Background:

    • Vascular calcification is common and a predictor of mortality in dialysis patients.
    • The mechanisms underlying vascular calcification are not fully understood.
    • Irisin, a myokine, is a potential factor in vascular calcification among hemodialysis patients.

    Purpose of the Study:

    • To evaluate serum irisin levels in hemodialysis patients.
    • To determine the relationship between serum irisin and vascular calcification.
    • To identify other parameters associated with vascular calcification in hemodialysis patients.

    Main Methods:

    • Cross-sectional study of 150 hemodialysis patients and 38 healthy controls.
    • Serum irisin concentrations measured using ELISA.
    • Abdominal aortic calcification scores used to assess vascular calcification.

    Main Results:

    • Hemodialysis patients had significantly lower serum irisin levels compared to controls.
    • Lower irisin concentrations were observed in hemodialysis patients with vascular calcification.
    • Serum irisin, hemodialysis vintage, and age were independent risk factors for vascular calcification.

    Conclusions:

    • This study provides the first clinical evidence linking serum irisin to vascular calcification in hemodialysis patients.
    • Low irisin levels, prolonged hemodialysis, and advanced age are identified as independent risk factors.
    • Irisin may serve as a potential biomarker for vascular calcification in hemodialysis patients.
    Abstract

    Keywords:
    CardiovascularChronic kidney diseaseHemodialysisIrisinVascular calcification

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