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Published on: April 8, 2013
Endogenous Adenosine May Be Related to Left Ventricular Dysfunction, Dilation, and Wall Thinning in Patients With
Yujiro Kinomura1, Toshiki Tanaka1, Takuma Aoyama1
1Department of Cardiology, Gifu University Graduate School of Medicine.
Insights
Elevated plasma adenosine concentrations are linked to impaired left ventricular (LV) systolic function, LV dilation, and thinner LV walls in cardiac patients, suggesting a role for endogenous adenosine in heart disease progression.
Area of Science:
- Cardiology
- Biochemistry
- Physiology
Background:
- The role of endogenous adenosine in cardiac conditions remains largely undefined.
- Investigating adenosine's impact on cardiac structure and function is crucial for understanding heart disease.
Purpose of the Study:
- To explore the association between plasma adenosine levels and left ventricular (LV) function, dilation, and wall thickness in cardiac patients.
- To determine if endogenous adenosine plays a role in the pathophysiology of various heart conditions.
Main Methods:
- Plasma adenosine concentrations were quantified using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
- Echocardiography was employed to assess LV ejection fraction (EF), end-diastolic dimension (LVDd), posterior wall thickness (LVPWth), and interventricular septum thickness (IVSth).
- Analysis included 97 patients with conditions like angina, myocardial infarction, and cardiomyopathies.
Main Results:
- Higher plasma adenosine concentrations were observed in patients with reduced LV ejection fraction (<47%) and LV dilation (LVDd ≥50 mm).
- Plasma adenosine levels showed an inverse correlation with interventricular septum thickness (IVSth) and LV posterior wall thickness (LVPWth).
- Patients with thinner LV walls (IVSth <8 mm and LVPWth <8 mm) exhibited significantly higher plasma adenosine concentrations.
Conclusions:
- Endogenous adenosine may be implicated in the development of left ventricular dysfunction, dilation, and wall thinning in cardiac patients.
- These findings suggest a potential link between adenosine and adverse cardiac remodeling and function.
Background:
The role of endogenous adenosine in cardiac patients is still unclear, so we investigated the relationship between the plasma adenosine concentration and left ventricular (LV) function, LV dilation and LV wall thinning in cardiac patients.
Methods And Results:
In 97 cardiac patients, with angina pectoris, old myocardial infarction, dilated or hypertrophic cardiomyopathy, and valvular heart disease, plasma adenosine concentrations were measured using the LC-MS/MS system, and the LV function, LV end-diastolic dimension (LVDd), LV posterior wall thickness (LVPWth), and interventricular septum thickness (IVSth) were assessed by echocardiography. The plasma adenosine concentration was significantly higher in patients with a LV ejection fraction (EF), an indicator of the LV systolic function, <47% compared with those with LVEF ≥47% (P=0.027). There was no difference between the plasma adenosine concentration and E/e', an indicator of LV diastolic function. The plasma adenosine concentration was significantly higher in patients with LVDd ≥50 mm than in those with LVDd <50 mm (P=0.030). The plasma adenosine concentration was inversely correlated with IVSth (P=0.003) and LVPWth (P=0.0007). The plasma adenosine concentration was significantly higher in patients with IVSth <8 mm than in those with IVSth ≥8 mm (P=0.015), and was significantly higher in patients with LVPWth <8 mm than in those with LVPWth ≥8 mm (P=0.020).
Conclusions:
Endogenous adenosine may be related to LV dysfunction, dilation, and wall thinning in cardiac patients.
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