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Brain Mapping Using a Graphene Electrode Array
Published on: October 20, 2023
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New thin-film surface electrode array enables brain mapping with high spatial acuity in rodents.
W S Konerding1, U P Froriep2, A Kral3
1Institute of AudioNeuroTechnology and Department of Experimental Otology, ENT Clinics, Stadtfelddamm 34, Hannover Medical School, 30625, Hannover, Germany. konerding.wiebke@mh-hannover.de.
Scientific Reports
|March 2, 2018
Summary
New electrocorticography (ECoG) grids offer high-quality recordings in the auditory cortex, matching penetrating electrode arrays (PEAs) for tonotopic mapping and multi-unit activity, while minimizing neuronal damage.
Area of Science:
- Neuroscience
- Electrophysiology
- Auditory Cortex Research
Background:
- Traditional penetrating electrode arrays (PEAs) offer high resolution but cause neuronal damage.
- Electrocorticography (ECoG) surface grids allow simultaneous recording but have limited spatial resolution.
- Thin-film parylene C ECoG grids represent a novel approach to overcome ECoG limitations.
Purpose of the Study:
- To compare the performance of new thin-film ECoG grids with traditional PEAs.
- To evaluate the ECoG grids' capability for tonotopic mapping and recording multi-unit activity (MUA).
- To assess the signal quality and depth correlation of ECoG recordings.
Main Methods:
- Simultaneous recordings were made using thin-film ECoG grids and PEAs in the guinea pig primary auditory cortex.
- ECoG grid local field potentials (LFPs) and MUA were compared with PEA recordings.
- Tonotopic mapping and signal-to-depth correlations were analyzed.
Main Results:
- ECoG grids demonstrated higher response thresholds and amplitudes compared to PEAs.
- ECoG enabled fast and reliable tonotopic mapping, with tuning widths similar to PEAs.
- ECoG signals correlated with supragranular layers, and MUA recordings showed advantages over LFP, including sharper frequency tuning.
Conclusions:
- Thin-film ECoG grids provide high-quality electrophysiological recordings in the auditory cortex.
- ECoG grids offer a less invasive alternative to PEAs for detailed auditory cortex mapping.
- Simultaneous recording of LFP and MUA is feasible with ECoG grids, enabling comprehensive neural analysis.
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