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Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
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Berberine nanoparticles with enhanced in vitro bioavailability: characterization and antimicrobial activity
Muhammad Umar Khayam Sahibzada1,2, Abdul Sadiq2, Hani S Faidah3
1Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Pakistan.
Drug Design, Development and Therapy
|March 2, 2018
Summary
Berberine nanoparticles significantly improved solubility and dissolution rates, enhancing antibacterial activity. The evaporative precipitation of nanosuspension (EPN) method yielded superior results compared to anti-solvent precipitation with a syringe pump (APSP).
Area of Science:
- Pharmacology
- Materials Science
- Nanotechnology
Background:
- Berberine, a traditional medicine compound, suffers from poor oral bioavailability due to low solubility and dissolution.
- This limits its therapeutic efficacy for conditions like hypertension and inflammation.
Purpose of the Study:
- To enhance berberine's solubility, dissolution rate, and bioavailability.
- To evaluate the antibacterial activity of berberine nanoparticles (NPs).
Main Methods:
- Preparation of berberine NPs using evaporative precipitation of nanosuspension (EPN) and anti-solvent precipitation with a syringe pump (APSP).
- Characterization using differential scanning calorimetry (DSC) and X-ray powder diffractometry (XRD).
- Solubility, dissolution, and antibacterial activity assessments.
Main Results:
- Nanoparticles (NPs) exhibited increased solubility and dissolution rates.
- Conversion from crystalline to semi-crystalline form contributed to improved properties.
- Berberine NPs demonstrated significant antibacterial activity against Gram-positive and Gram-negative bacteria and yeasts.
Conclusions:
- Both APSP and EPN methods produced berberine NPs with promising antibacterial activity.
- EPN-prepared NPs showed superior efficacy compared to APSP-prepared NPs and unprocessed berberine.
- Nanoparticle formulation effectively addresses berberine's bioavailability challenges.
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