Restorin^® NR is a Highly Efficient NAD⁺ Precursor

Area of Science:

• Biochemistry
• Aging Research
• Pharmacology

Background:

• Nicotinamide adenine dinucleotide (NAD+) is crucial for cellular function, and its decline with age is linked to age-related diseases.
• Oral supplementation with NAD+ precursors like nicotinamide riboside (NR) shows promise, but NR has poor circulatory stability.
• There is a need for more stable and effective NAD+ precursor forms.

Purpose of the Study:

• To evaluate Restorin NR, a novel crystalline NR fumarate, as a potential NAD+ enhancer.
• To compare the efficacy of Restorin NR against other NAD+ precursors, specifically nicotinamide mononucleotide (NMN) and NR chloride.
• To assess the impact of these precursors on NAD+ levels in an aged murine model.

Main Methods:

• An aged murine model was used to compare three NAD+ precursors: NMN, NR chloride, and Restorin NR.
• Different dosages were administered, including 0.33 mmol/kg/day and 1 mmol/kg/day.
• Circulating NAD+ levels were measured to determine the efficacy of each precursor.

Main Results:

• Restorin NR significantly increased NAD+ levels compared to equivalent doses of NMN or NR chloride.
• A low dose of Restorin NR (0.33 mmol/kg/day) achieved NAD+ elevation comparable to higher doses of NMN or NR chloride.
• At a matched dose (1 mmol/kg/day), Restorin NR produced significantly higher circulating NAD+ levels than the other precursors.

Conclusions:

• Restorin NR is a novel crystalline salt form of NR with enhanced NAD+ boosting capabilities.
• Restorin NR demonstrates superior efficacy in increasing circulating NAD+ levels compared to NMN and NR chloride.
• Restorin NR represents a promising therapeutic agent for enhancing NAD+ levels and potentially combating aging.