Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitochondria01:37

Mitochondria

13.3K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
13.3K
Aging01:26

Aging

1.1K
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
1.1K
Replicative Cell Senescence02:15

Replicative Cell Senescence

3.0K
3.0K
Replicative Cell Senescence02:15

Replicative Cell Senescence

3.5K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
3.5K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.5K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.5K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

351
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
351

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated effects of altered action potentials and calcium release on skeletal muscle force generation in transgenic Huntington's disease mice.

Pflugers Archiv : European journal of physiology·2026
Same author

Voltage sensor current, SR Ca<sup>2+</sup> release, and Ca<sup>2+</sup> channel current during trains of action potential-like depolarizations of skeletal muscle fibers.

Physiological reports·2023
Same author

<i>KIT</i> genetic alterations in breast cancer.

Journal of clinical pathology·2022
Same author

Longitudinal analysis of aqueous humour cytokine expression and OCT-based imaging biomarkers in retinal vein occlusions treated with anti-vascular endothelial growth factor therapy in the IMAGINE study.

Eye (London, England)·2022
Same author

Low prevalence of influenza A strains with resistance markers in Brazil during 2017-2019 seasons.

Frontiers in public health·2022
Same author

In Depth Viral Diversity Analysis in Atypical Neurological and Neonatal Chikungunya Infections in Rio de Janeiro, Brazil.

Viruses·2022

Related Experiment Video

Updated: Apr 22, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

6.1K

SRN-901, a Novel Longevity Drug, Extends Lifespan and Healthspan by Targeting Multiple Aging Pathways.

Brett Weiss1, Daniel R Miranda1, Dylan Arrazati1

  • 1Seragon Biosciences, Irvine, CA, USA.

Drug Design, Development and Therapy
|April 21, 2026
PubMed
Summary

A novel drug combination, SRN-901, significantly extended median lifespan by 33% and reduced frailty by 70% in aging mice. This intervention targets multiple aging pathways, offering a promising approach to enhance longevity and healthspan.

Keywords:
NAD+SRN-901autophagyhealthspanlifespanlongevitymTORmitophagysenolytics

More Related Videos

Measuring Caenorhabditis elegans Life Span in 96 Well Microtiter Plates
12:23

Measuring Caenorhabditis elegans Life Span in 96 Well Microtiter Plates

Published on: March 18, 2011

38.4K
Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

5.5K

Related Experiment Videos

Last Updated: Apr 22, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

6.1K
Measuring Caenorhabditis elegans Life Span in 96 Well Microtiter Plates
12:23

Measuring Caenorhabditis elegans Life Span in 96 Well Microtiter Plates

Published on: March 18, 2011

38.4K
Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

5.5K

Area of Science:

  • Gerontology and aging research
  • Pharmacology and drug development
  • Molecular biology and genetics

Background:

  • Aging is a complex process involving multiple interconnected biological systems.
  • Existing interventions often target single pathways, limiting their efficacy in extending lifespan and healthspan.
  • A combinatorial approach may better address the multifaceted nature of aging.

Purpose of the Study:

  • To evaluate the effects of the novel oral drug SRN-901 on lifespan, frailty, and aging-related molecular and metabolic changes.
  • To assess SRN-901's impact on gene expression pathways associated with aging and age-related diseases.
  • To determine if SRN-901 can mitigate age-related metabolic dysregulation.

Main Methods:

  • 18-month-old mice fed a Western diet were treated with SRN-901, a combination of urolithin A, quercetin, nicotinamide riboside, alpha-lipoic acid, and SRN-820.
  • Lifespan, frailty scores, gene expression (transcriptomics), and metabolic profiles (metabolomics) were analyzed.
  • Statistical analyses, including Cox proportional hazards models, were used to assess treatment effects.

Main Results:

  • SRN-901 treatment increased median remaining lifespan by 33% (hazard ratio 0.54) and attenuated frailty progression by 70%.
  • Transcriptomic analysis revealed modulation of aging-related pathways, including inflammation, apoptosis, DNA repair, and neurodegeneration.
  • Metabolic profiling indicated that SRN-901 normalized age-related metabolic shifts, promoting a younger metabolic profile and enhancing glutathione metabolism.

Conclusions:

  • SRN-901 demonstrates significant efficacy in extending lifespan and improving healthspan in a mouse model of aging.
  • The multi-compound nature of SRN-901 allows it to target diverse aging pathways simultaneously.
  • SRN-901 represents a promising therapeutic candidate for interventions aimed at delaying aging and promoting longevity.