Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nuclear Stability03:18

Nuclear Stability

23.4K
Protons and neutrons, collectively called nucleons, are packed together tightly in a nucleus. With a radius of about 10−15 meters, a nucleus is quite small compared to the radius of the entire atom, which is about 10−10 meters. Nuclei are extremely dense compared to bulk matter, averaging 1.8 × 1014 grams per cubic centimeter. If the earth’s density were equal to the average nuclear density, the earth’s radius would be only about 200 meters.
To hold positively charged protons together...
23.4K
RNA Stability01:53

RNA Stability

35.8K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
35.8K
Stability01:28

Stability

425
The time response of a linear time-invariant (LTI) system can be divided into transient and steady-state responses. The transient response represents the system's initial reaction to a change in input and diminishes to zero over time. In contrast, the steady-state response is the behavior that persists after the transient effects have faded.
The stability of an LTI system is determined by the roots of its characteristic equation, known as poles. A system is stable if it produces a bounded...
425
Stability of structures01:14

Stability of structures

534
In mechanical engineering, the stability of systems under various forces is critical for designing durable and efficient structures. One fundamental way to explore these concepts is by analyzing systems like two rods connected at a pivot point, O, with a torsional spring of spring constant k at the pivot point. This system is similar in appearance to a scissor jack used to change tires on a car. In this case, the arms of the linkage (equivalent to the rods in this system) are entirely vertical,...
534
Pole and System Stability01:24

Pole and System Stability

1.0K
The transfer function is a fundamental concept representing the ratio of two polynomials. The numerator and denominator encapsulate the system's dynamics. The zeros and poles of this transfer function are critical in determining the system's behavior and stability.
Simple poles are unique roots of the denominator polynomial. Each simple pole corresponds to a distinct solution to the system's characteristic equation, typically resulting in exponential decay terms in the system's...
1.0K
Multimachine Stability01:25

Multimachine Stability

584
Multimachine stability analysis is crucial for understanding the dynamics and stability of power systems with multiple synchronous machines. The objective is to solve the swing equations for a network of M machines connected to an N-bus power system.
In analyzing the system, the nodal equations represent the relationship between bus voltages, machine voltages, and machine currents. The nodal equation is given by:
584

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A high-gain Y-shaped patch array with an 8-port MIMO configuration for pattern diversity in mm-wave applications.

Scientific reports·2026
Same author

5G RF-EMFs Mitigate UV-Induced Genotoxic Stress Through Redox Balance and p38 Pathway Regulation in Skin Cells.

Antioxidants (Basel, Switzerland)·2026
Same author

ZAP-X Stereotactic Radiosurgery: The Initial Experience Involving 200 Patients.

Cureus·2026
Same author

Objective quality assessment on angular spectrum for holographic fringe pattern.

Optics express·2025
Same author

Initial Outcomes of Zap-X Stereotactic Radiosurgery for the Treatment of Spinal Tumors: A Case Series.

Cureus·2025
Same author

ZAP-X Stereotactic Radiosurgery for Optic Nerve Sheath Meningioma: A Case Report.

Cureus·2025

Related Experiment Video

Updated: Feb 13, 2026

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3.7K

Assessing Cerebral Hemodynamic Stability After Brain Injury.

Bianca Pineda1, Colin Kosinski1, Nam Kim1

  • 1Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.

Acta Neurochirurgica. Supplement
|March 2, 2018
PubMed
Summary

The RAP index reliably measures intracranial pressure dynamics after brain injury, identifying instability with 74% accuracy. This validated tool aids in predicting hemodynamic instability.

Keywords:
AutoregulationBrain injuryCerebral hemodynamicsCompensatory reserveIntracranial pressure (ICP)Pressure-volume relationshipPulsatility

More Related Videos

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants
11:39

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

Published on: March 14, 2013

21.1K
Simultaneous Evaluation of Cerebral Hemodynamics and Light Scattering Properties of the In Vivo Rat Brain Using Multispectral Diffuse Reflectance Imaging
07:06

Simultaneous Evaluation of Cerebral Hemodynamics and Light Scattering Properties of the In Vivo Rat Brain Using Multispectral Diffuse Reflectance Imaging

Published on: May 7, 2017

8.1K

Related Experiment Videos

Last Updated: Feb 13, 2026

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3.7K
Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants
11:39

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

Published on: March 14, 2013

21.1K
Simultaneous Evaluation of Cerebral Hemodynamics and Light Scattering Properties of the In Vivo Rat Brain Using Multispectral Diffuse Reflectance Imaging
07:06

Simultaneous Evaluation of Cerebral Hemodynamics and Light Scattering Properties of the In Vivo Rat Brain Using Multispectral Diffuse Reflectance Imaging

Published on: May 7, 2017

8.1K

Area of Science:

  • Neuroscience
  • Critical Care Medicine
  • Biomedical Engineering

Background:

  • Cerebral hemodynamics can become unstable after brain injury, marked by intracranial pressure (ICP) fluctuations.
  • The RAP index, correlating ICP pulse amplitude (A) and mean pressure (P), is a potential indicator of these changes.
  • Previous studies questioned the RAP index's consistency and prognostic value due to measurement concerns.

Purpose of the Study:

  • To assess the consistency of the RAP index in measuring intracranial hemodynamics.
  • To determine if the RAP index has prognostic value in predicting hemodynamic instability post-brain injury.

Main Methods:

  • The RAP index was calculated for seven brain-injured patients in a surgical ICU.
  • ICP data was segmented into hourly periods, classified as stable or unstable based on sharp rises (≥0.15 mmHg/s).
  • Pearson's correlation coefficient between ICP pulse amplitude and mean ICP was computed using 6-second windows.

Main Results:

  • Average ICP and amplitude levels did not significantly differ between stable and unstable periods.
  • RAP values exceeding 0.6 accurately identified unstable periods with a positive predictive value of 74%.
  • The RAP index proved more effective than ICP or amplitude alone in distinguishing instability.

Conclusions:

  • The RAP index offers a valid measure of ICP dynamics, unaffected by sensor drift.
  • It demonstrates prognostic capability in identifying hemodynamic instability following brain injury.
  • This validated index enhances the monitoring of critical care patients with brain injuries.