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Related Concept Videos

X-ray Imaging01:24

X-ray Imaging

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German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...
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Updated: May 5, 2026

Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy
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ZAP-X Stereotactic Radiosurgery: The Initial Experience Involving 200 Patients.

Timothy Chen1, Patrick Pema2, Michael Chaga1

  • 1Radiation Oncology, Jersey Shore University Medical Center, Neptune, USA.

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|January 5, 2026
PubMed
Summary
This summary is machine-generated.

The ZAP-X platform demonstrates feasibility and safety for cranial stereotactic radiosurgery (SRS), showing high patient satisfaction and effective treatment of diverse brain tumors. This study supports ZAP-X as a viable SRS alternative.

Keywords:
gyroscopicradiosurgerysrsstereotactic radiosurgeryzap-x

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Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Medical Physics

Background:

  • The ZAP-X is a novel dedicated cranial stereotactic radiosurgery (SRS) platform.
  • Conventional SRS platforms include Gamma Knife (GK) and CyberKnife (CK).
  • Evaluating new SRS technologies is crucial for advancing treatment options.

Purpose of the Study:

  • To assess the feasibility, safety, clinical and dosimetric performance, and patient satisfaction of the ZAP-X SRS platform.
  • To evaluate the ZAP-X workflow in a real-world clinical setting.
  • To compare ZAP-X performance against established SRS systems.

Main Methods:

  • A prospective study involving 200 patients with 374 intracranial targets treated using the ZAP-X platform.
  • Data collected included patient demographics, tumor types, treatment parameters, dosimetric indices, and patient-reported outcomes.
  • Utilized Efficast head and shoulder masks for improved patient comfort and alignment.

Main Results:

  • High gamma passing rates (98.5%) and favorable conformity indices (CI=1.3, PCI=0.77) were achieved.
  • Average treatment time was 50 minutes, with setup time being a key predictor.
  • Patient satisfaction scores were high (4.7-5.0/5), with fatigue and headache as common side effects.

Conclusions:

  • The ZAP-X platform is a feasible, safe, and effective option for cranial SRS across various pathologies.
  • The system demonstrated excellent dosimetric performance and high patient satisfaction.
  • Further multi-institutional studies are warranted to confirm long-term outcomes and solidify ZAP-X's role in SRS.