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[Diffusion of piperacillin in the healthy human peritoneum after administration of a prophylactic dose]
Presse Medicale (Paris, France : 1983)
|December 20, 1986
Abstract:
The passage of piperacillin into the omentum was evaluated in 23 patients who received one single intravenous injection of 2 grams. Median concentrations were 7.05 micrograms.g-1 at 30 min, 7.2 micrograms.g-1 at 60 min., 4.65 micrograms.g-1 at 90 min. and 3.53 micrograms.g-1 at 120 min. The corresponding maximal values were 36 micrograms.g-1, 59.7 micrograms.g-1, 36 micrograms.g-1 and 32 micrograms.g-1 respectively. Specimens collected beyond 2 hours showed that the concentrations obtained were maintained.
Insights
Piperacillin effectively penetrates the omentum following intravenous administration. Omental tissue concentrations of piperacillin remain stable for over two hours post-injection.
Area of Science:
- Pharmacokinetics
- Surgical Infection Prophylaxis
- Antibiotic Tissue Penetration
Context:
- Understanding antibiotic distribution in surgical sites is crucial for effective infection management.
- The omentum plays a significant role in abdominal defense and inflammatory responses.
- Limited data exists on piperacillin concentrations within omental tissue.
Purpose:
- To quantify piperacillin concentrations in human omental tissue after a single intravenous dose.
- To assess the pharmacokinetic profile of piperacillin in the omentum.
Summary:
- Piperacillin (2 grams IV) was administered to 23 patients, with omental tissue samples collected at various time points.
- Median piperacillin concentrations ranged from 3.53 to 7.2 µg/g, peaking at 60 minutes.
- Maximal concentrations reached up to 59.7 µg/g, with sustained levels beyond 2 hours.
Impact:
- Provides essential data on piperacillin's efficacy in treating or preventing infections involving the omentum.
- Informs optimal dosing strategies for surgical prophylaxis and intra-abdominal infections.
- Highlights piperacillin's potential for achieving therapeutic concentrations in this critical anatomical site.