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[Evaluation of bile diffusion of piperacillin]
Presse Medicale (Paris, France : 1983)
|December 20, 1986
Summary
Piperacillin demonstrates excellent distribution into the biliary tract, with high concentrations found in bile and gallbladder tissue after intravenous administration. This makes piperacillin a potentially effective antibiotic for treating biliary tract infections.
Area of Science:
- Pharmacology
- Microbiology
Context:
- Cholecystectomy patients provide a model for studying drug distribution in the biliary system.
- Biliary tract infections are common and require effective antibiotic therapy.
Purpose:
- To quantify piperacillin concentrations in serum, bile, and gallbladder tissue.
- To assess the distribution of piperacillin within the biliary tract.
Summary:
- Piperacillin (2g IV) concentrations were measured in 10 cholecystectomy patients.
- Mean concentrations: serum (81.7 µg/ml), choledochal bile (382 µg/ml), gallbladder bile (30.8 µg/ml), gallbladder tissue (10.5 µg/g).
- High choledochal bile to serum ratio (4.7) indicates good biliary penetration.
Impact:
- Piperacillin exhibits favorable distribution in the biliary tract.
- Its properties suggest efficacy against common pathogens causing biliary tract infections.