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Related Experiment Videos

[Indications for piperacillin in pediatrics].

T May, P Canton

    Presse Medicale (Paris, France : 1983)
    |December 20, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Piperacillin demonstrated significant clinical effectiveness in treating severe pediatric infections, achieving an 85% cure or improvement rate. This antibiotic was well-tolerated, showing promise for specific pediatric cases, especially when combined with aminoglycosides.

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    Area of Science:

    • Pediatric Infectious Diseases
    • Clinical Pharmacology
    • Bacteriology

    Context:

    • Severe infections in children pose significant clinical challenges.
    • Accurate bacteriological diagnosis is crucial for effective treatment.
    • Piperacillin is a broad-spectrum penicillin antibiotic.

    Purpose:

    • To evaluate the clinical efficacy and tolerability of piperacillin in pediatric patients with severe infections.
    • To determine optimal dosing and combination therapy regimens.

    Summary:

    • A study assessed piperacillin in 34 children with severe infections (septicaemia, meningitis, etc.).
    • Treatment involved a mean of 220 mg/kg/day for 11 days, often combined with aminoglycosides.
    • 85% of patients showed clinical cure or improvement with good tolerability.

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    Impact:

    • Piperacillin shows potential for treating severe Gram-negative infections in pediatric patients with cystic fibrosis or neutropenia.
    • It is also recommended for intensive care unit-acquired infections or febrile leucopenia in children, particularly when combined with aminoglycosides pending bacteriological results.