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Published on: August 12, 2012
Sensing, Transport and Other Potential Biomedical Applications of Pseudopeptides
Enrico Faggi1, Santiago V Luis2, Ignacio Alfonso1
1Department of Biological Chemistry and Molecular Modelling, Institute of Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Cientificas, Barcelona, Spain.
Abstract:
Pseudopeptides are privileged synthetic molecules built from the designed combination of peptide-like and abiotic artificial moieties. Consequently, they are benefited from the advantages of both families of chemical structures: modular synthesis, chemical and functional diversity, tailored three-dimensional structure, usually high stability in biological media and low non-specific toxicity. Accordingly, in the last years, these compounds have been used for different biomedical applications, ranging from bio-sensing, ion transport, the molecular recognition of biologically relevant species, drug delivery or gene transfection. This review highlights a selection of the most remarkable and recent advances in this field.
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