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Updated: Feb 13, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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An updated systematic review and meta-analysis of early outcomes after left atrial appendage occlusion

Charan Yerasi1, Mohamad Lazkani2, Prathik Kolluru3

  • 1St. Joseph's Hospital and Medical Center, Phoenix, Arizona.

Journal of Interventional Cardiology
|March 2, 2018
PubMed

Insights

Left atrial appendage occlusion (LAAO) is a safe and effective stroke prevention method for non-valvular atrial fibrillation (NVAF) patients. This meta-analysis confirms LAAO

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Stroke Prevention

Background:

  • Left atrial appendage occlusion (LAAO) offers a promising alternative for stroke prevention in patients with non-valvular atrial fibrillation (NVAF).
  • Existing studies on early LAAO outcomes present variable results, necessitating a comprehensive summary.

Purpose of the Study:

  • To conduct an updated meta-analysis summarizing the early outcomes of Left Atrial Appendage Occlusion (LAAO).

Main Methods:

  • A systematic search of Medline/PubMed, Ovid Journals, Clinical Trials, Abstract Meetings, and Cochrane databases was performed.
  • The search covered literature published from January 1, 1999, to November 30, 2016.

Main Results:

  • The meta-analysis included 49 studies with 12,415 patients, with a median age of 73.5 years. Successful LAAO implantation was achieved in 96.3% of patients.
  • Pooled outcomes included all-cause mortality at 0.28%, all-cause stroke at 0.31%, major bleeding at 1.71%, and pericardial effusion at 3.25%.
  • Sub-analysis of randomized trials showed LAAO devices had lower mortality compared to warfarin, with similar bleeding risks.

Conclusions:

  • Left atrial appendage occlusion (LAAO) is demonstrated to be a safe and effective strategy for stroke prevention in patients diagnosed with non-valvular atrial fibrillation (NVAF).
Abstract

Keywords:
atrial fibrillationearly outcomesleft atrial appendage closure devicesmajor bleedingmortalitystroke prevention

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