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[Family history and risk of coronary heart disease]

J H Si1, R R Meng1, C Q Yu1

  • 1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.

Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi
|March 2, 2018
PubMed

Insights

A family history of heart disease significantly increases the risk of major coronary events (MCE) and ischemic heart disease (IHD). This risk is higher for individuals with a history of disease among siblings, especially if overweight or smokers.

Area of Science:

  • Cardiovascular Epidemiology
  • Genetics of Heart Disease
  • Public Health

Background:

  • Family history is a known, yet often underutilized, predictor of cardiovascular disease.
  • Understanding the specific impact of family history on major coronary events (MCE) and ischemic heart disease (IHD) in diverse populations is crucial for targeted prevention.

Purpose of the Study:

  • To investigate the association between family history and the risk of developing MCE and IHD.
  • To explore how factors like parental vs. sibling history, overweight/obesity, and smoking status modify this association.

Main Methods:

  • A prospective cohort study of 485,784 participants from the China Kadoorie Biobank.
  • Cox regression analysis was employed to calculate hazard ratios (HR) and 95% confidence intervals (CI) for MCE and IHD.
  • Subgroup analyses were conducted to assess the influence of baseline characteristics on the observed associations.

Main Results:

  • Family history was independently associated with an increased risk of MCE (adjusted HR: 1.41, 95% CI: 1.19-1.65) and IHD (adjusted HR: 1.25, 95% CI: 1.18-1.33).
  • A history of disease among siblings showed a stronger association with early-onset MCE (HR: 2.97, 95% CI: 1.80-4.88) compared to parental history.
  • The association between family history and MCE/IHD was more pronounced in overweight/obese individuals and smokers.

Conclusions:

  • Family history is a significant, independent risk factor for MCE and IHD in the Chinese population.
  • Public health strategies should emphasize lifestyle interventions and chronic disease management, particularly for individuals with a positive family history of heart disease.

Keywords:
Coronary heart diseaseFamily historyIschemic heart diseaseMajor coronary events

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