Related Experiment Video For DNA methylation
Updated: Feb 13, 2026

ATAC-Seq Optimization for Cancer Epigenetics Research
Published on: June 30, 2022
Current Insights into Oral Cancer Epigenetics
Alexandra Iulia Irimie1, Cristina Ciocan2, Diana Gulei3
1Department of Prosthetic Dentistry and Dental Materials, Division Dental Propaedeutics, Aesthetics, Faculty of Dentistry, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400001 Cluj-Napoca, Romania. iulia.irimie@umfcluj.ro.
Abstract:
Epigenetic modifications have emerged into one of the cancer hallmarks, replacing the concept of malignant pathologies as being solely genetic-based conditions. The epigenetic landscape is responsible for normal development but also for the heterogeneity among tissues in terms of gene expression patterns. Dysregulation in these mechanisms has been associated with disease stage, and increased attention is now granted to cancer in order to take advantage of these modifications in terms of novel therapeutic strategies or diagnosis/prognosis tools. Oral cancer has also been subjected to epigenetic analysis with numerous studies revealing that the development and progression of this malignancy are partially induced by an altered epigenetic substrate together with genetic alterations and prolonged exposure to environmental risk factors. The present review summarizes the most important epigenetic modifications associated with oral cancer and also their potential to be used as new therapeutic targets.
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