Related Experiment Video

Updated: Feb 13, 2026

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
05:19

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

11.0K

Preventive Potential of Resveratrol in Carcinogen-Induced Rat Thyroid Tumorigenesis

Xu Zheng1, Bin Jia2, Xue Song3

  • 1Liaoning Laboratory of Cancer Genetics and Epigenetics and Department of Cell Biology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China. dyzhengxu@yeah.net.

Nutrients
|March 3, 2018
PubMed

Insights

Resveratrol administration, via intragastric or intraperitoneal injection, effectively reduced thyroid cancer lesions in rats. This natural compound shows promise for thyroid tumor prevention by modulating key molecular pathways.

Area of Science:

  • Endocrinology
  • Oncology
  • Chemoprevention

Background:

  • Thyroid cancer (TC) is the most common endocrine malignancy.
  • No reliable preventive agents currently exist for TC.
  • Resveratrol demonstrates in vitro anti-TC activity, but its in vivo effects on thyroid tumorigenesis are unknown.

Purpose of the Study:

  • To investigate the preventive effects of resveratrol on thyroid tumorigenesis using a rat model.
  • To evaluate resveratrol's efficacy when administered via intragastric (IG) and intraperitoneal (IP) routes.

Main Methods:

  • A diethylnitrosamine (DEN)/ N-methyl-N-nitrosourea (MNU)/ N-propyl-N-nitrosamine (DHPN)-induced rat carcinogenesis model was employed.
  • Rats received DEN/MNU/DHPN treatment, followed by resveratrol via IG or IP injection for 30 weeks.
  • Thyroid tissue resveratrol concentrations, tumor incidence, serum markers (CEA, Tg), and molecular markers (IL-6, COX-2, NF-κB/p65, IkBα) were analyzed.

Main Results:

  • Resveratrol concentrations in thyroid tissue were 1.278 ± 0.419 nmol/g (IG) and 1.752 ± 0.398 nmol/g (IP).
  • Thyroid cancer-related lesions decreased from 53.3% (no resveratrol) to 33.3% (IG) and 26.7% (IP).
  • Resveratrol treatment lowered serum CEA and Tg, down-regulated IL-6 and COX-2, reduced NF-κB/p65 translocation, and increased IkBα expression.

Conclusions:

  • Both IG and IP resveratrol administration significantly reduced the frequency and severity of thyroid cancer lesions in the rat model.
  • Resveratrol demonstrates potential as a preventive agent for thyroid tumors.
  • The findings suggest resveratrol's chemopreventive value in thyroid cancer.
Keywords:
chemopreventionresveratrolthyroid tumorigenesis

More Related Videos

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.5K
Spontaneous Murine Model of Anaplastic Thyroid Cancer05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.3K

Related Concept Videos

Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
2.0K
The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
7.8K
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.2K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.8K
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
1.3K
Preventive Healthcare Services01:30

Preventive Healthcare Services

Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
2.2K