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Related Concept Videos

System of Memory01:23

System of Memory

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Memory is categorized into three major systems: sensory memory, short-term memory (STM), and long-term memory (LTM). These systems differ in their capacity and the duration for which they can hold information. Sensory memory captures raw sensory input from the environment, holding it for just a few seconds or less. For example, on hearing a brief, loud sound, like a car horn honking, the sound seems to linger in the mind for a moment even after it stops. This is an instance of sensory memory...
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Working Memory01:24

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Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
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Long-Term Memory01:18

Long-Term Memory

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Long-term memory is a relatively permanent type of memory, capable of storing vast amounts of information over extended periods. Its storage capacity is generally considered unlimited.
Long-term memory can be categorized into two primary types: explicit and implicit memory. Explicit memory, also known as declarative memory, involves the conscious recollection of information that we deliberately try to remember, recall, and articulate. This type of memory encompasses specific facts, events, and...
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Traumatic Memory01:20

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Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual...
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Repressed Memory01:16

Repressed Memory

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Repressed memories are a psychological phenomenon where memories of traumatic events are unconsciously blocked from a person's awareness. This process occurs as a defense mechanism, protecting the mind from the emotional impact of distressing or painful experiences. For example, a person who has experienced childhood trauma may grow up with no conscious recollection of the event. In such cases, the memories are thought to be buried deep within the subconscious, inaccessible to the conscious...
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Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
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Related Experiment Video

Updated: Feb 13, 2026

A Real-world What-Where-When Memory Test
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A Real-world What-Where-When Memory Test

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Memory allocation mechanisms underlie memory linking across time.

M Sehgal1, M Zhou1, A Lavi1

  • 1Departments of Neurobiology, Psychology, Psychiatry and Biobehavioral Sciences, Integrative Center for Learning and Memory and Brain Research Institute, UCLA, Los Angeles, CA 90095, United States.

Neurobiology of Learning and Memory
|March 3, 2018
PubMed
Summary
This summary is machine-generated.

This review explores how memories are linked and integrated over time. It highlights cellular mechanisms like CREB and intrinsic excitability that support memory consolidation and later recall.

Keywords:
AllocationCREBIntrinsic excitabilityMemory linking

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Molecular Biology

Background:

  • Memory is dynamic, requiring alteration, linking, and integration into semantic knowledge.
  • Existing research extensively covers single memory encoding, retrieval, and updating.
  • Mechanisms governing the linking and integration of multiple memories over extended periods remain less understood.

Purpose of the Study:

  • To review evidence on the mechanisms underlying memory linking and integration.
  • To explore how specific molecular and cellular processes facilitate the connection of memories over time.
  • To identify factors that promote effective recall and linking of memories.

Main Methods:

  • Literature review of studies on memory allocation, CREB, and intrinsic excitability.
  • Analysis of research investigating phenomena related to memory linking.
  • Synthesis of findings on cellular and molecular mechanisms in memory consolidation.

Main Results:

  • Specific memory allocation mechanisms, including changes in CREB (cAMP response element-binding protein) and intrinsic excitability, are crucial for memory storage.
  • These mechanisms ensure that memories are stored in a manner that facilitates later recall and linking.
  • Other biological phenomena also show potential roles in the process of memory linking.

Conclusions:

  • Cellular mechanisms like CREB and intrinsic excitability play a vital role in enabling memories to be linked and integrated.
  • Understanding these processes is key to comprehending how the brain forms a cohesive representation of the world.
  • Further research into various phenomena may uncover additional insights into memory linking.