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Functional Connectivity Changes in Systemic Lupus Erythematosus: A Resting-State Study.

Jessika Nystedt1,2, Peter Mannfolk3, Andreas Jönsen4

  • 11 Department of Clinical Sciences , Lund/Diagnostic Radiology, Lund University, Lund, Sweden .

Brain Connectivity
|March 3, 2018
PubMed
Summary
This summary is machine-generated.

Systemic lupus erythematosus (SLE) patients show altered brain connectivity, particularly in default mode and executive networks. Neuropsychiatric SLE patients exhibit more pronounced hypoconnectivity, potentially explaining neurological symptoms.

Keywords:
MRINPSLESLEbrain connectivityfunctional MRI

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Area of Science:

  • Neuroscience
  • Radiology
  • Immunology

Background:

  • Systemic lupus erythematosus (SLE) is a complex autoimmune disease with potential neurological manifestations.
  • Neuropsychiatric lupus (NPSLE) presents a significant clinical challenge, impacting patient quality of life.
  • Understanding the neural underpinnings of SLE and NPSLE is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate resting-state functional connectivity (rsFC) in female lupus patients compared to healthy controls.
  • To explore correlations between rsFC alterations and disease duration, activity (SLEDAI-2k), and organ damage (SDI).
  • To differentiate rsFC patterns in lupus patients with and without neuropsychiatric symptoms.

Main Methods:

  • Recruited 61 female lupus patients and 20 age/gender-matched healthy controls.
  • Utilized 3T anatomical and resting-state functional MRI (fMRI) scans.
  • Performed whole-brain voxelwise functional connectivity analysis with permutation testing.

Main Results:

  • Lupus patients displayed widespread hypo- and hyperconnectivity across crucial brain networks.
  • Reduced connectivity was observed within the default mode network (DMN) and central executive network (CEN), and between them.
  • Increased connectivity was noted within and between sensory-motor networks; hypoconnectivity was more severe in patients with neuropsychiatric symptoms.

Conclusions:

  • Systemic lupus erythematosus is associated with significant alterations in brain functional connectivity.
  • Neuropsychiatric lupus patients exhibit distinct patterns of hypoconnectivity, potentially underlying neurological symptoms.
  • Observed connectivity changes may result from neuronal damage and/or compensatory rewiring mechanisms.