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Who Defends the Stem Cell's Citadel?
Hélène Strick-Marchand1, David Durantel2
1Innate Immunity Unit, Institut Pasteur, 75724, Paris, France; INSERM U1223, Paris, France.
Cell Stem Cell
|March 3, 2018
Abstract:
Recently in Cell, Wu et al. (2018) demonstrated that intrinsic expression of a subset of interferon stimulated genes confers resistance to viral infections in stem cells both in vitro and in vivo, while differentiated cells lose this intrinsic gatekeeper expression pattern in favor of inducible interferon responses.