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Novel Dimeric Capsid Assembly Modulators as a Unique Class of Highly Potent Anti-HBV Agents

Franck Amblard1, Zhe Chen1, Kalouna Kra2,3

  • 1Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Atlanta, Georgia 30322, United States.

Journal of Medicinal Chemistry
|November 6, 2025
PubMed
Summary

New dimeric capsid assembly modulators (D-CAMs) show promise for treating chronic hepatitis B virus (HBV) infection. D-CAM-14 demonstrated enhanced potency and unique effects on HBV capsid assembly compared to existing therapies.

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