Related Experiment Video
Updated: Feb 13, 2026
06:26
Analysis of Side Population in Solid Tumor Cell Lines
Published on: February 23, 2021
4.8K
Prognostic value of DcR3 in solid tumors: A meta-analysis
Hua Ge1, Chaojie Liang1, Shulin Ren1
1Department of general surgery, Beijing Tongren hospital, Capital Medical University, Beijing, People's Republic of China.
Summary
Increased expression of Decoy receptor 3 (DcR3) in solid tumors is linked to poorer overall survival for cancer patients. This suggests DcR3 is a potential biomarker for predicting cancer prognosis.
Area of Science:
- Oncology
- Molecular Biology
- Biomarker Discovery
Background:
- Decoy receptor 3 (DcR3) is frequently overexpressed in various solid tumors.
- This overexpression suggests a significant role for DcR3 in cancer development and progression.
Purpose of the Study:
- To evaluate the association between Decoy receptor 3 (DcR3) expression and patient prognosis in solid tumors.
- To synthesize existing evidence through a meta-analysis.
Main Methods:
- A comprehensive literature search was conducted across major scientific databases (PubMed, Web of Science, Cochrane Library, EMBASE, CNKI, Wan Fang).
- Pooled hazard ratios (HRs) for overall survival (OS) and recurrence-free survival (RFS) were calculated.
- Fixed and random effects models were employed for data analysis.
Main Results:
- Analysis of 16 studies involving 2209 patients revealed a significant correlation between DcR3 overexpression and worse overall survival (OS).
- However, DcR3 expression did not appear to be significantly related to recurrence-free survival (RFS) in the analyzed malignancies.
Conclusions:
- Elevated DcR3 expression is associated with poor prognosis in cancer patients.
- DcR3 expression status can serve as a valuable biomarker for predicting prognosis in patients with solid tumors.
Related Concept Videos
02:37Metallic Solids
20.9K
Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
20.9K
02:22Structures of Solids
18.6K
Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
18.6K
02:18Network Covalent Solids
16.2K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K
02:54Molecular and Ionic Solids
20.3K
Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
20.3K
01:09Directing Effect of Substituents: meta-Directing Groups
6.1K
Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
6.1K
02:26Molecular Comparison of Gases, Liquids, and Solids
55.7K
Particles in a solid are tightly packed together (fixed shape) and often arranged in a regular pattern; in a liquid, they are close together with no regular arrangement (no fixed shape); in a gas, they are far apart with no regular arrangement (no fixed shape). Particles in a solid vibrate about fixed positions (cannot flow) and do not generally move in relation to one another; in a liquid, they move past each other (can flow) but remain in essentially constant contact; in a gas, they move...
55.7K