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Microbial Production of l-Serine from Renewable Feedstocks
Xiaomei Zhang1, Guoqiang Xu2, Jinsong Shi3
1The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China; Laboratory of Pharmaceutical Engineering, School of Pharmaceutics, Jiangnan University, Wuxi 214122, China; These authors contributed equally to this work and should be considered as co-first authors.
Abstract:
l-Serine is a non-essential amino acid that has wide and expanding applications in industry with a fast-growing market demand. Currently, extraction and enzymatic catalysis are the main processes for l-serine production. However, such approaches limit the industrial-scale applications of this important amino acid. Therefore, shifting to the direct fermentative production of l-serine from renewable feedstocks has attracted increasing attention. This review details the current status of microbial production of l-serine from renewable feedstocks. We also summarize the current trends in metabolic engineering strategies and techniques for the typical industrial organisms Corynebacterium glutamicum and Escherichia coli that have been developed to address and overcome major challenges in the l-serine production process.
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