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Visible light reduces C. elegans longevity.

C Daniel De Magalhaes Filho1,2, Brian Henriquez2, Nicole E Seah3

  • 1The Howard Hughes Medical Institute, Molecular and Cell Biology Department, Li Ka Shing Center, University of California Berkeley, Berkeley, CA, 94720, USA.

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|March 4, 2018
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Visible light exposure shortens the lifespan of the nematode Caenorhabditis elegans by inducing photooxidative stress. Long-lived mutants and antioxidant-treated worms show increased resistance to this light-induced stress.

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Area of Science:

  • Biology
  • Genetics
  • Physiology

Background:

  • The nematode Caenorhabditis elegans is known to sense UV and blue-violet light, altering its behavior.
  • The impact of low-intensity visible light on C. elegans physiology and longevity remains largely unexplored.

Purpose of the Study:

  • To investigate the role of low-intensity visible light exposure on the lifespan of Caenorhabditis elegans.
  • To elucidate the underlying mechanisms of light-induced lifespan reduction and identify factors influencing resistance.

Main Methods:

  • Exposure of C. elegans to varying durations of visible light.
  • Assessment of lifespan across different light conditions.
  • Analysis of genetic factors (circadian control, lite-1, tax-2) and physiological responses (photooxidative stress, unfolded-protein response).
  • Evaluation of resistance in long-lived mutants and antioxidant-supplemented wild-type worms.

Main Results:

  • C. elegans lifespan is inversely correlated with exposure time to visible light.
  • Visible light induces photooxidative stress and a general unfolded-protein response, leading to lifespan reduction.
  • Circadian control, lite-1, and tax-2 are not responsible for this lifespan reduction.
  • Long-lived mutants and worms treated with antioxidants exhibit enhanced resistance to visible light stress.

Conclusions:

  • Transparent nematodes like C. elegans are sensitive to visible light radiation.
  • Visible light exposure poses an unrecognized bias in laboratory lifespan studies.
  • Standardization of light control methods is crucial for accurate C. elegans longevity research.