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How to Characterize the Function of a Brain Region.
Sarah Genon1, Andrew Reid2, Robert Langner1
1Institute of Neuroscience and Medicine (INM-1, INM-7), Research Centre Jülich, Jülich, Germany; Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Trends in Cognitive Sciences
|March 5, 2018
Summary
This study proposes a new method to formally define brain region functions by integrating neuroimaging data with behavioral analysis. This approach aims to reveal the computational role of brain areas in human behavior.
Area of Science:
- Neuroscience
- Cognitive Science
- Computational Biology
Background:
- Current understanding of brain region functions is fragmented across disciplines.
- A formal framework linking brain regions to specific human behaviors is needed.
- Existing methods lack a unified approach to define 'function'.
Purpose of the Study:
- To develop a comprehensive method for formalizing brain region functions.
- To bridge the gap between neuroimaging findings and behavioral relevance.
- To understand the computational role of brain regions in human behavior.
Main Methods:
- Reviewing diverse scientific fields and their conceptions of brain function.
- Aggregating neuroimaging activation data across various experimental conditions.
- Analyzing covariation between brain region features and large-sample behavioral data.
Main Results:
- A novel perspective for determining behavioral associations of brain regions.
- Characterization of functional engagement of brain regions through aggregated data.
- Identification of links between brain structure/activity and complex behaviors.
Conclusions:
- Integrating neuroimaging and behavioral phenotyping offers a powerful approach to define brain region functions.
- This combined methodology can elucidate the broader role of brain regions in large-scale functional networks.
- The proposed framework advances our understanding of the brain-behavior relationship.
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