Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Limiting Reactant02:27

Limiting Reactant

70.6K
The relative amounts of reactants and products represented in a balanced chemical equation are often referred to as stoichiometric amounts. However, in reality, the reactants are not always present in the stoichiometric amounts indicated by the balanced equation.
70.6K
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

6.9K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
6.9K
The Number e as a Limit01:29

The Number e as a Limit

102
The number e is a fundamental constant in calculus, playing a central role in describing continuous change, particularly exponential growth. It is most naturally defined through its relationship with the natural logarithm, which is the inverse of the exponential function with base e. This relationship allows e to be characterized using basic principles of differentiation rather than as an arbitrary numerical constant.A key property of the natural logarithm function, ln x, is that its derivative...
102
Types of Limits I01:23

Types of Limits I

209
Limits are a key mathematical concept for understanding how functions behave as their input approaches specific values, particularly when the function is undefined. They help reveal trends and discontinuities by examining the values a function approaches rather than its actual value.One-sided limits focus on the direction from which a value is approached. When a function behaves differently depending on whether the input approaches from the left or the right, the two one-sided limits may not...
209
Limit Laws I01:25

Limit Laws I

233
Limit laws provide essential tools for analyzing how functions behave as their input approaches a specific value. These laws are particularly useful when dealing with combinations of functions, provided the individual limits exist. The Sum and Difference Laws state that the limit of the sum or difference of two functions equals the sum or difference of their respective limits:The Product Law asserts that the limit of the product of two functions equals the product of their individual limits:A...
233
Limits at Infinity01:24

Limits at Infinity

338
The function that decreases as the input becomes very large provides a clear example of how mathematical functions can behave at extreme values. When the input increases continuously, the output becomes smaller and smaller, getting closer to a particular fixed value. Although the output never actually reaches this value, it moves nearer to it without limit. This behavior is a fundamental concept in understanding how functions behave as the input grows indefinitely. The graphical representation...
338

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a low-cost external fixation system: an off-label solution for resource-limited settings.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2026
Same author

SPARC in Musculoskeletal Tissues: Linking Matrix Assembly to Disease.

Matrix biology : journal of the International Society for Matrix Biology·2026
Same author

Contractility patterns on functional lumen imaging probe prior to peroral endoscopic myotomy predict outcomes in achalasia.

Gastrointestinal endoscopy·2026
Same author

The Role of Phagocytic Cells in the Achilles Tendon.

International journal of molecular sciences·2026
Same author

Efficacy of azacitidine in meningiomas and explorative analyses of underlying molecular mechanisms.

Neurosurgical review·2026
Same author

Beyond tendon interfaces - Functional divergence of the matricellular protein SPARC.

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft·2025
Same journal

Silicone oil in protein drug products and its implications for formulation stability.

Advanced drug delivery reviews·2026
Same journal

Targeted delivery of proteolysis-targeting chimeras (PROTAC) and molecular glue degraders (MGD).

Advanced drug delivery reviews·2026
Same journal

Lysosome-targeting degrader delivery system: from formulation design to biomedical applications.

Advanced drug delivery reviews·2026
Same journal

Anti-PEG antibodies in nanomedicine: Mechanisms, risks, and opportunities.

Advanced drug delivery reviews·2026
Same journal

Optimizing macrophage-targeted intracellular delivery systems for safe and effective immunotherapies.

Advanced drug delivery reviews·2026
Same journal

Light-controlled CRISPR-dCas9 epigenome editing: advanced drug-delivery strategies and oncology applications.

Advanced drug delivery reviews·2026
See all related articles

Related Experiment Video

Updated: Feb 13, 2026

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
07:40

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Published on: April 28, 2022

3.3K

Limiting angiogenesis to modulate scar formation.

Stefanie Korntner1, Christine Lehner1, Renate Gehwolf1

  • 1Institute of Tendon and Bone Regeneration, Paracelsus Medical University - Spinal Cord Injury & Tissue Regeneration Center Salzburg, Salzburg, Austria; Austrian Cluster for Tissue Regeneration, Vienna, Austria.

Advanced Drug Delivery Reviews
|March 5, 2018
PubMed
Summary
This summary is machine-generated.

Understanding angiogenesis, the formation of new blood vessels, is crucial for tissue repair. Controlling vessel growth, especially in avascular tissues, can improve healing and prevent scarring.

Keywords:
AngiogenesisCartilageCorneaEmbryonic vascularisationFetalFibrotic responseScar-free healingScarringTendonVEGF

More Related Videos

Endothelial Cell Tube Formation Assay for the In Vitro Study of Angiogenesis
08:12

Endothelial Cell Tube Formation Assay for the In Vitro Study of Angiogenesis

Published on: September 1, 2014

61.9K
Rat Mesentery Angiogenesis Assay
18:30

Rat Mesentery Angiogenesis Assay

Published on: June 18, 2011

14.2K

Related Experiment Videos

Last Updated: Feb 13, 2026

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
07:40

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Published on: April 28, 2022

3.3K
Endothelial Cell Tube Formation Assay for the In Vitro Study of Angiogenesis
08:12

Endothelial Cell Tube Formation Assay for the In Vitro Study of Angiogenesis

Published on: September 1, 2014

61.9K
Rat Mesentery Angiogenesis Assay
18:30

Rat Mesentery Angiogenesis Assay

Published on: June 18, 2011

14.2K

Area of Science:

  • Regenerative Medicine
  • Vascular Biology
  • Tissue Engineering

Background:

  • Angiogenesis, the formation of new blood vessels, is vital for tissue repair and wound healing.
  • During wound healing, an immature vascular plexus forms and is later pruned by vessel regression.
  • Dysregulated angiogenesis, including excessive vessel growth or impaired regression, can lead to scarring and impaired function.

Purpose of the Study:

  • To understand the molecular and cellular mechanisms of physiological angiogenesis from induction to resolution.
  • To identify targetable factors that promote functional tissue regeneration.
  • To investigate the role of angiogenesis control in avascular tissue repair.

Main Methods:

  • Review of current literature on angiogenesis in wound healing.
  • Analysis of molecular and cellular signaling pathways involved in vessel formation and regression.
  • Examination of outcomes in avascular tissues with modulated angiogenesis.

Main Results:

  • Uncontrolled vessel growth or impaired regression, often due to inflammation, hinders wound healing.
  • Understanding the complete angiogenic process is key to identifying therapeutic targets.
  • Limiting angiogenesis in avascular tissue repair may optimize functional recovery.

Conclusions:

  • Targeting specific molecular and cellular factors is essential for promoting functional tissue regeneration.
  • Modulating angiogenesis, particularly by limiting vessel growth in avascular tissues, can lead to better long-term healing outcomes.
  • Further research into the resolution phase of angiogenesis is needed to develop effective regenerative strategies.