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Genetically encoded fluorescent voltage indicators: are we there yet?

Jelena Platisa1, Vincent A Pieribone2

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Genetically encoded voltage indicators (GEVIs) enable large-scale neural recordings for understanding brain activity and behavior. This review addresses key questions for advancing GEVI technology beyond initial proof-of-concept studies for broader adoption.

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Area of Science:

  • Neuroscience
  • Biotechnology

Background:

  • Understanding brain activity requires large-scale, high-resolution neuronal recordings.
  • Genetically encoded voltage indicators (GEVIs) offer a minimally invasive method for chronic neuronal activity monitoring.
  • Existing GEVIs show promise, but further development is needed for widespread adoption.

Purpose of the Study:

  • To identify crucial questions for advancing GEVI technology.
  • To guide future GEVI development and application beyond proof-of-principle studies.

Main Methods:

  • Review of current GEVI technology and applications.
  • Identification of critical areas for improvement in GEVI development.
  • Discussion of challenges and future directions for GEVI implementation.

Main Results:

  • Identified key areas for GEVI improvement, including signal-to-noise ratio, photostability, and genetic targeting.
  • Highlighted the need for standardized in vivo testing protocols.
  • Discussed strategies for enhancing GEVI performance for chronic, large-scale recordings.

Conclusions:

  • Addressing specific development and application questions is crucial for GEVI technology's broad adoption.
  • Further research is needed to optimize GEVI properties for robust in vivo neural recording.
  • GEVIs hold significant potential for advancing our understanding of brain function and behavior.