Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complement System01:27

Complement System

11.0K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
11.0K
Complementation Tests00:49

Complementation Tests

6.3K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
6.3K
Components of Language01:24

Components of Language

831
Language, whether spoken, signed, or written, consists of specific components: lexicon and grammar. The lexicon is the vocabulary of a language, comprising its words. Grammar is the set of rules used to convey meaning through the lexicon. For example, English grammar adds “-ed” to most verbs to indicate past tense. Words are formed by combining phonemes, which are the basic sound units of a language. Different languages have different sets of phonemes (e.g., “ah” vs.
831
Components of Stress01:23

Components of Stress

556
Stress analysis under multiple loading conditions is intricate, necessitating a comprehensive grasp of normal and shearing stresses. Consider a small cube at point O, subjected to stress on all six faces, visible or not. Normal stress components σx, σy, σz act perpendicularly to the x, y, and z axes. Shearing stress components τxy and τxz are exerted on faces perpendicular to these axes.
Interestingly, the hidden cube faces also experience these stresses, equal and...
556
Role of Septins01:02

Role of Septins

2.2K
Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
2.2K
The Role of Culture01:23

The Role of Culture

441
Culture plays a crucial role in shaping self-identity and influencing thought and behavior, a foundational interest within social psychology. The multicultural perspective recognizes that individuals do not exist in a vacuum; instead, their experiences, perceptions, and actions are deeply influenced by the intersecting dimensions of their cultural, ethnic, and social group affiliations.Cultural Influence on Self-Identity and Social PerceptionCultural frameworks inform how individuals define...
441

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Engineered atopic dermatitis models for recreating hypoxic conditions in atopic dermatitis microenvironments.

Bioactive materials·2026
Same author

In vivo mitochondrial base editing restores genotype and visual function in a mouse model of LHON.

Nature communications·2025
Same author

Alterations in mitochondrial base editors enhance targeted editing efficiency for mouse model generation.

Molecular therapy. Nucleic acids·2025
Same author

Coordinated gene expression within sustained STAT3-associated chromatin conformations contributes to hepatocellular carcinoma progression.

Cancer communications (London, England)·2025
Same author

Targeting eRNA-Producing Super-Enhancers Regulates TNFα Expression and Mitigates Chronic Inflammation in Mice and Patient-Derived Immune Cells.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Caspases as master regulators of programmed cell death: apoptosis, pyroptosis and beyond.

Experimental & molecular medicine·2025
Same journal

Intranasal Delivery of an RSV A2-Derived Pre-F VLP Vaccine Induces Robust Mucosal and Systemic Immunity Against RSV B Strain Without Enhanced Disease.

Immune network·2026
Same journal

Selective Enrichment of Non-Canonical Vγ9-Jγ2 TRG Clonotypes in Clear Cell Renal Cell Carcinoma With Shorter CDR3 Loops.

Immune network·2026
Same journal

Regulation of T Cell Senescence in Health and Diseases.

Immune network·2026
Same journal

Apoptotic-Cell Accumulation and Mertk Expression Are Linked to Diminished Antiviral CD8<sup>+</sup> T Cell Immunity in Chronic Infections.

Immune network·2026
Same journal

Respiratory Microbiome Remodeling in Aging: Implications for Immunosenescence and Therapeutic Intervention.

Immune network·2026
Same journal

Synergistic Induction of Neutrophilic Inflammatory Programs by <i>Staphylococcus aureus</i> and Cigarette Smoke in Airway Epithelial Cells.

Immune network·2026
See all related articles

Related Experiment Video

Updated: Feb 13, 2026

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
06:54

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

Published on: June 15, 2019

6.4K

Beyond the Role of CD55 as a Complement Component.

So Hee Dho1, Jae Cheong Lim1, Lark Kyun Kim2

  • 1Radioisotope Research Division, Department of Research Reactor Utilization, Korea Atomic Energy Research Institute, Daejeon 34057, Korea.

Immune Network
|March 6, 2018
PubMed
Summary
This summary is machine-generated.

Decay-accelerating factor (DAF or CD55) is crucial for regulating the immune system. This review explores CD55

Keywords:
CD55CancerComplementImmunotherapyMalaria

More Related Videos

Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

22.7K
Functional Complementation Analysis FCA: A Laboratory Exercise Designed and Implemented to Supplement the Teaching of Biochemical Pathways
09:27

Functional Complementation Analysis FCA: A Laboratory Exercise Designed and Implemented to Supplement the Teaching of Biochemical Pathways

Published on: June 24, 2016

18.2K

Related Experiment Videos

Last Updated: Feb 13, 2026

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
06:54

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

Published on: June 15, 2019

6.4K
Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

22.7K
Functional Complementation Analysis FCA: A Laboratory Exercise Designed and Implemented to Supplement the Teaching of Biochemical Pathways
09:27

Functional Complementation Analysis FCA: A Laboratory Exercise Designed and Implemented to Supplement the Teaching of Biochemical Pathways

Published on: June 24, 2016

18.2K

Area of Science:

  • Immunology
  • Molecular Biology
  • Pathology

Background:

  • The complement system is a vital part of innate immunity, traditionally viewed as a non-specific defense against pathogens.
  • Decay-accelerating factor (DAF or CD55) is a key regulator of complement activation.
  • Emerging evidence highlights CD55's involvement in diverse pathological conditions beyond its role in pathogen clearance.

Purpose of the Study:

  • To review the current understanding of Decay-accelerating factor (DAF or CD55) and its multifaceted roles.
  • To elucidate the specific involvement of CD55 in various human diseases.
  • To provide insights into potential therapeutic strategies targeting CD55 for disease diagnosis and treatment.

Main Methods:

  • Literature review of existing research on CD55.
  • Analysis of studies investigating CD55's function in immune regulation.
  • Examination of clinical data linking CD55 to disease pathogenesis.

Main Results:

  • CD55 deficiency can cause protein-losing enteropathy, leading to complement hyperactivation, malabsorption, and thrombosis.
  • CD55 serves as a critical host receptor for malaria parasite infection.
  • CD55's interaction with CD97 and its presence on various cells link it to cancer, malaria, protein-losing enteropathy, paroxysmal nocturnal hemoglobinuria, and autoimmune diseases.

Conclusions:

  • CD55 plays a significant, often overlooked, role in regulating immune responses and maintaining physiological homeostasis.
  • Dysregulation of CD55 is implicated in the pathogenesis of numerous diseases, presenting therapeutic opportunities.
  • Further research into CD55's functions may lead to novel diagnostic and therapeutic interventions for associated conditions.