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Selective Enrichment of Non-Canonical Vγ9-Jγ2 TRG Clonotypes in Clear Cell Renal Cell Carcinoma With Shorter CDR3

Won Joon Oh1,2, Seong Il Seo2,3, H K Imashi Chamathka1,2

  • 1Department of Immunology, Graduate School of Basic Medical Science, Sungkyunkwan University School of Medicine, Suwon 16419, Korea.

Immune Network
|July 6, 2026
PubMed
Abstract

No abstract available in PubMed .

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

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