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Updated: Feb 13, 2026

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Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance
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Remarkable visual recovery after severe open globe injury
Yewlin E Chee1, Justin M Kanoff2, Dean Eliott1
1Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, United States.
American Journal of Ophthalmology Case Reports
|March 6, 2018
Summary
Remarkable visual recovery occurred after severe open globe injury, even from no light perception. This case highlights potential for vision improvement with secondary vitreoretinal surgery.
Area of Science:
- Ophthalmology
- Retinal Surgery
Background:
- Open globe injuries represent a significant cause of vision loss.
- Poor presenting visual acuity is a well-established predictor of poor outcomes.
Observation:
- A 70-year-old male sustained a severe open globe injury.
- Initial presentation revealed no light perception (NLP) vision, persisting post-primary repair.
- The patient underwent secondary vitreoretinal surgery for total retinal detachment with a 360° giant retinal tear and incarceration.
Findings:
- Post-secondary surgery, visual acuity improved significantly to 20/60 pinhole to 20/50.
- This represents a remarkable recovery from a pre-operative NLP state.
Implications:
- This case suggests that even in severe open globe injuries with initial NLP vision, significant visual recovery is possible.
- The presence of massive choroidal hemorrhage may have contributed to the unexpected positive outcome.
- Secondary vitreoretinal surgery can be a viable option for salvaging vision in complex cases.
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