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08:39
Culture of Bladder Cancer Organoids as Precision Medicine Tools
Published on: December 28, 2021
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Nanomaterials for Cancer Precision Medicine.
Yilong Wang1, Shuyang Sun2, Zhiyuan Zhang2
1The Institute for Translational Nanomedicine, Shanghai East Hospital, the Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai, 200092, P. R. China.
Advanced Materials (Deerfield Beach, Fla.)
|March 6, 2018
Summary
Precision medicine utilizes nanomaterials for targeted cancer therapy by identifying oncogenes with next-generation sequencing. MicroRNA replacement therapy delivered via nanocarriers offers a molecularly-defined approach to cancer treatment.
Area of Science:
- Nanotechnology and Materials Science
- Oncology
- Genetics
Background:
- Medical science advances enable precise molecular-level diagnosis and therapeutics.
- Precision medicine emerges, presenting challenges addressable by novel nanomaterials.
Purpose of the Study:
- To present a nanoscience approach to precision medicine, focusing on cancer therapy.
- To introduce "molecularly-defined cancers" and their treatment via nanocarriers.
Main Methods:
- Utilizing next-generation sequencing to identify cancer-driving oncogenes.
- Applying microRNA replacement therapy with nanocarriers to regulate oncogenes.
- Assessing treatment outcomes using patient-derived xenograft models.
Main Results:
- Demonstrated a novel therapeutic strategy targeting molecularly-defined cancers.
- Showcased the potential of nanocarriers in delivering microRNA for oncogene regulation.
- Validated precision cancer therapy through genetically characterized xenograft models.
Conclusions:
- Nanoscience offers a powerful platform for precision cancer medicine.
- Challenges remain in nanomaterial design, functionalization, and delivery for effective cancer therapeutics.
- This approach represents a paradigm shift from conventional cancer treatments.
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