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A putative role for Discoidin Domain Receptor 1 in cancer chemoresistance

Chiara Ambrogio1, Elodie Darbo2, Sam W Lee3

  • 1a Department of Medical Oncology , Dana-Farber Cancer Institute , Boston , MA , USA.

Cell Adhesion & Migration
|March 6, 2018
PubMed

Insights

Discoidin Domain Receptor 1 (DDR1) promotes cancer cell survival, potentially causing resistance to chemotherapy. Inhibiting DDR1 may offer therapeutic benefits in cancer treatment by overcoming this resistance.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Discoidin Domain Receptor 1 (DDR1) is a receptor tyrosine kinase involved in cell adhesion, proliferation, survival, migration, and invasion.
  • Dysregulation of DDR1, through mutations or overexpression, is linked to human diseases, notably cancer.

Purpose of the Study:

  • To explore the role of DDR1-dependent pro-survival functions in the development of cancer resistance to chemotherapy.
  • To speculate on the molecular mechanisms underlying DDR1's contribution to chemoresistance.

Main Methods:

  • Literature review and discussion of existing pre-clinical data.
  • Analysis of DDR1's known functions in cell signaling pathways.
  • Hypothesizing molecular mechanisms of DDR1-mediated chemoresistance.

Main Results:

  • Pharmacological inhibition of DDR1 has shown therapeutic benefits in pre-clinical cancer models.
  • DDR1's pro-survival signaling may contribute to cancer cells evading chemotherapeutic agents.
  • Specific molecular pathways mediating DDR1's role in chemoresistance are proposed.

Conclusions:

  • DDR1 plays a significant role in promoting cancer cell survival.
  • Targeting DDR1 presents a potential strategy to overcome chemoresistance in cancer therapy.
  • Further research into DDR1's molecular mechanisms is warranted to develop effective anti-cancer treatments.
Keywords:
Discoidin Domain Receptor 1RTK signallingcancerchemoresistancereceptor crosstalk

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