Monolithic Multiband CMUTs for Photoacoustic Computed Tomography With In Vivo Biological Tissue Imaging

Among the biomedical imaging modalities, photoacoustic computed tomography (PACT) was one of the emerging hybrid techniques in recent years. In designing the PACT imaging system, a finite-bandwidth transducer is one of the limited factors for the overall performance. As the target size is inversely proportional to the dominant frequency components of the generated photoacoustic (PA) signal, a broad bandwidth transducer is desired for different scales' imaging. In this paper, a monolithic multiband capacitive micromachined ultrasonic transducer (CMUT) array was designed and fabricated for the reception of the wideband PA signals so as to provide high-resolution images with high-frequency CMUT arrays and present the high signal-to-noise-ratio major structure with low-frequency CMUT arrays. To demonstrate its performance, a phantom experiment was conducted to show and evaluate the various qualities of multiresolution images. In addition, an in vivo mouse model experiment was also carried out for revealing the multiscale PA imaging capability with the multiband CMUTs on biological tissues. From the obtained results, the images from different CMUT arrays could show the structures of the mouse brain in different scales. In addition, the images from the high-frequency CMUT arrays were able to reveal the major blood vasculatures, whereas the images from low-frequency CMUT arrays showed the gross macroscopic anatomy of the brain with higher contrast.