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Analysis of prognostic factors of patients with malignant peritoneal mesothelioma
Wenjie Yin1, Guoqi Zheng2, Kunna Yang3
1Department of Gastroenterology, Cangzhou Central Hospital, Cangzhou, Hebei, 061001, China.
Background:
The study aims to find out independent prognostic factors for patients with malignant peritoneal mesothelioma (MPeM).
Methods:
Patients with pathologically proven MPeM were retrospectively reviewed. Potential prognostic factors were analyzed, including age, gender, asbestos exposure, body mass index (BMI), treatment, and laboratory results, such as blood routine examination and liver functions. The influences of various risk factors on the prognoses were analyzed by univariate analysis. A Cox regression model analysis established independent factors for the survival prognosis of the patients.
Results:
Seventy MPeM patients, including 33 patients who received intraperitoneal chemotherapy with cisplatin, 14 patients who received systemic chemotherapy with cisplatin + pemetrexed, and 21 untreated patients were included in this study. The 1-year survival was 32.9%, the 2-year survival was 10%, and the 3-year survival was 2.9%. The median age of MPeM was 62 years, and the female-to-male ratio was 1:0.56. The univariate and multivariate analyses showed that treatment, albumin (ALB), and blood neutrophil-to-lymphocyte ratio (NLR) were independent factors that affected the overall survival (OS) of MPeM patients.
Conclusion:
High blood NLR and hypoalbuminemia are adverse prognostic factors for MPeM patients. Systemic chemotherapy and intraperitoneal chemotherapy can prolong the survival period.
Insights
High blood neutrophil-to-lymphocyte ratio (NLR) and low albumin levels are poor prognostic indicators for malignant peritoneal mesothelioma (MPeM). Chemotherapy, both systemic and intraperitoneal, can improve survival outcomes for MPeM patients.
Area of Science:
- Oncology
- Medical Research
Background:
- Malignant peritoneal mesothelioma (MPeM) is a rare and aggressive cancer.
- Identifying prognostic factors is crucial for patient management and treatment strategies.
Purpose of the Study:
- To identify independent prognostic factors for patients diagnosed with malignant peritoneal mesothelioma (MPeM).
- To evaluate the impact of various clinical and laboratory parameters on patient survival.
Main Methods:
- Retrospective review of pathologically confirmed MPeM patients.
- Univariate and Cox regression analyses were performed to assess prognostic factors.
- Key factors analyzed included age, gender, asbestos exposure, BMI, treatment, and laboratory results (blood routine, liver function).
Main Results:
- Seventy MPeM patients were analyzed, with varying treatment groups (intraperitoneal chemotherapy, systemic chemotherapy, untreated).
- Overall survival rates were low: 1-year (32.9%), 2-year (10%), and 3-year (2.9%).
- Independent prognostic factors identified were treatment, albumin (ALB), and neutrophil-to-lymphocyte ratio (NLR).
Conclusions:
- Elevated blood neutrophil-to-lymphocyte ratio (NLR) and hypoalbuminemia are adverse prognostic indicators in MPeM.
- Both systemic and intraperitoneal chemotherapy demonstrate potential to extend survival periods for MPeM patients.
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