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Updated: Feb 13, 2026

A Two-interval Forced-choice Task for Multisensory Comparisons
Published on: November 9, 2018
Chlorthalidone, not hydrochlorothiazide, is the right diuretic for comparison
Ravi Tejraj Mehta1, Anil Pareek1, Indranil Purkait1
1Ipca Laboratories Limited, Mumbai, India.
Abstract:
We have read the study design "Comparison of effects between calcium channel blocker and diuretics in combination with angiotensin II receptor blocker on 24-h central blood pressure and vascular hemodynamic parameters in hypertensive patients: study design for a multicenter, double-blinded, active controlled, phase 4, randomized trial" by Oh GC, et al. with interest. The authors aim to compare the efficacy of amlodipine or hydrochlorothiazide (HCTZ) with an ARB. However, we wish to highlight that chlorthalidone (CTD) is the evidence-based and recommended anti-hypertensive diuretic, and should replace HCTZ in the trial to effectively compare efficacy against the CCB amlodipine.
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Multiple Comparison Tests
It would be easy to compare two samples using a significance alpha level of 0.05. In other words, there is only one sample pair to be compared. However, it would be difficult to identify a significantly different sample if the number...

