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Perinatal factors and the development of childhood asthma

Ahra Kim1, Gina Lim2, Inbo Oh1

  • 1Environmental Health Center, University of Ulsan College of Medicine, Ulsan, Republic of Korea.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|March 7, 2018
PubMed

Insights

Early life oxygen therapy and breastfeeding significantly influence childhood asthma development. These perinatal factors interact with environmental exposures like tobacco smoke and air pollution, impacting asthma risk.

Area of Science:

  • Pediatric Allergy and Immunology
  • Environmental Health
  • Epidemiology

Background:

  • Asthma development is suspected to be influenced by perinatal factors, but robust evidence is lacking.
  • Previous studies lacked sufficient power to investigate these associations.

Purpose of the Study:

  • To determine the independent and combined effects of perinatal factors and other risk factors on asthma development.
  • To investigate the impact of early life exposures on long-term asthma risk.

Main Methods:

  • A cohort of 3,770 children (mean age 9.1 years) was analyzed, comparing asthma and non-asthma groups.
  • Multivariate analyses and subgroup analyses were employed to assess risk factors.

Main Results:

  • Early life oxygen therapy (aOR 1.864) and breastfeeding (aOR 0.763) were significant perinatal factors for asthma.
  • Environmental tobacco smoke (aOR 1.634) and parental allergic disease (aOR 1.882) were identified risk factors.
  • Combined effects were observed between perinatal factors and environmental/genetic risk factors.

Conclusions:

  • Early life oxygen therapy and breastfeeding are key perinatal factors influencing asthma development.
  • These perinatal factors interact with environmental tobacco smoke, traffic-related air pollution, parental allergic disease, and atopy, affecting asthma risk.
Abstract

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