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POEMS syndrome : a clinico pathological study.
A Vasanth1, Kps Nair1, A B Taly1
1Department of Neurology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore - 560 029, India.
Neurology India
|March 7, 2018
Summary
POEMS syndrome and Castleman
Area of Science:
- Neurology
- Oncology
Background:
- POEMS syndrome and Castleman's disease can present with chronic, progressive peripheral neuropathy.
- Papilloedema is a common feature in POEMS syndrome.
- Bone lesions are frequently observed in POEMS syndrome.
Purpose of the Study:
- To describe the clinical features of patients with POEMS syndrome and Castleman's disease presenting with peripheral neuropathy.
- To compare these features with existing literature.
- To emphasize diagnostic challenges and requirements.
Main Methods:
- Case series describing five patients with POEMS syndrome and one with Castleman's disease.
- Clinical examination, including assessment for papilloedema and bone lesions.
- Biopsy of bone lesions and lymph nodes for diagnosis.
Main Results:
- All five POEMS syndrome patients exhibited papilloedema.
- Four POEMS syndrome patients had bone lesions, confirmed by biopsy.
- The Castleman's disease patient showed angiofollicular lymphoid hyperplasia in lymph node biopsy.
- Therapeutic response was generally unsatisfactory.
Conclusions:
- POEMS syndrome and Castleman's disease require a high index of suspicion for diagnosis.
- Meticulous clinical examination and targeted investigations are crucial.
- Early and accurate diagnosis is essential for patient management.
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