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Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
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Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration
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Myocardial healing using cardiac fat.

Santiago Roura1,2,3, Carolina Gálvez-Montón1,3, Antoni Bayes-Genis1,3,4,5

  • 1a ICREC Research Program , Germans Trias i Pujol Health Research Institut , Badalona , Spain.

Expert Review of Cardiovascular Therapy
|March 7, 2018
PubMed
Summary
This summary is machine-generated.

Adipose graft transposition procedure (AGTP) offers a novel, safe, and cost-effective method for restoring cardiac function after myocardial infarction. This technique shows promise in preclinical and clinical trials for improving heart function and reducing tissue damage.

Keywords:
AGTPcardiac adipose tissuecardiac tissue engineeringmesenchymal stem cellsmyocardial infarction

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Area of Science:

  • Cardiovascular Research
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Chronic diseases like heart failure present significant socioeconomic burdens, necessitating innovative therapeutic strategies.
  • Current research explores cell therapy, stem cell conditioning, and cardiac tissue engineering for myocardial repair.
  • Myocardial infarction leads to scar formation and impaired cardiac function, requiring effective restorative interventions.

Purpose of the Study:

  • To review the restoration of cardiac function post-myocardial infarction using autologous cardiac adipose tissue grafts.
  • To evaluate the risks and benefits of cardiac adipose progenitors and the adipose graft transposition procedure (AGTP).
  • To discuss the transition from ex vivo progenitor manipulation to second-generation approaches like AGTP.

Main Methods:

  • Review of preclinical and clinical trial data on AGTP for ameliorating cardiac dysfunction.
  • Assessment of the safety and efficacy of AGTP in patients with myocardial infarction.
  • Analysis of the adipose graft transposition procedure (AGTP) as a therapeutic modality.

Main Results:

  • AGTP is a safe, inexpensive, and ethically sound second-generation therapeutic approach.
  • Preclinical and clinical trials indicate AGTP promotes cardiac function recovery and reduces myocardial necrosis.
  • The ongoing AGTP-2 trial (NCT02798276) aims to confirm AGTP's efficacy and patient outcomes.

Conclusions:

  • AGTP represents a promising, safe, and cost-effective strategy for cardiac repair after myocardial infarction.
  • This approach avoids risks associated with ex vivo progenitor manipulation.
  • Successful outcomes in the AGTP-2 trial could lead to widespread clinical adoption of AGTP.