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Updated: Feb 13, 2026
Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration
Published on: May 24, 2016
Myocardial healing using cardiac fat
Santiago Roura1,2,3, Carolina Gálvez-Montón1,3, Antoni Bayes-Genis1,3,4,5
1a ICREC Research Program , Germans Trias i Pujol Health Research Institut , Badalona , Spain.
Insights
Adipose graft transposition procedure (AGTP) offers a novel, safe, and cost-effective method for restoring cardiac function after myocardial infarction. This technique shows promise in preclinical and clinical trials for improving heart function and reducing tissue damage.
Area of Science:
- Cardiovascular Research
- Regenerative Medicine
- Tissue Engineering
Background:
- Chronic diseases like heart failure present significant socioeconomic burdens, necessitating innovative therapeutic strategies.
- Current research explores cell therapy, stem cell conditioning, and cardiac tissue engineering for myocardial repair.
- Myocardial infarction leads to scar formation and impaired cardiac function, requiring effective restorative interventions.
Purpose of the Study:
- To review the restoration of cardiac function post-myocardial infarction using autologous cardiac adipose tissue grafts.
- To evaluate the risks and benefits of cardiac adipose progenitors and the adipose graft transposition procedure (AGTP).
- To discuss the transition from ex vivo progenitor manipulation to second-generation approaches like AGTP.
Main Methods:
- Review of preclinical and clinical trial data on AGTP for ameliorating cardiac dysfunction.
- Assessment of the safety and efficacy of AGTP in patients with myocardial infarction.
- Analysis of the adipose graft transposition procedure (AGTP) as a therapeutic modality.
Main Results:
- AGTP is a safe, inexpensive, and ethically sound second-generation therapeutic approach.
- Preclinical and clinical trials indicate AGTP promotes cardiac function recovery and reduces myocardial necrosis.
- The ongoing AGTP-2 trial (NCT02798276) aims to confirm AGTP's efficacy and patient outcomes.
Conclusions:
- AGTP represents a promising, safe, and cost-effective strategy for cardiac repair after myocardial infarction.
- This approach avoids risks associated with ex vivo progenitor manipulation.
- Successful outcomes in the AGTP-2 trial could lead to widespread clinical adoption of AGTP.
Introduction:
Chronic diseases, including myocardial scar healing and heart failure remission, impose huge social and economic burdens, and novel approaches are needed. Several therapeutic modalities are currently being evaluated, including cell therapy, stem cell conditioning, and cardiac tissue engineering. Areas covered: This review discusses the restoration of cardiac function after myocardial infarction using a vascularized flap of autologous cardiac adipose tissue over an akinetic scar. It addresses the risks and benefits of using cardiac adipose progenitors and the adipose graft transposition procedure (AGTP) to ameliorate cardiac dysfunction in preclinical and clinical trials. Expert commentary: The focus is shifting from first-generation studies that used ex vivo expanded and manipulated progenitors to newer second-generation approaches, including AGTP, which are inexpensive and do not raise ethical issues. AGTP safety has been validated, and the ongoing AGTP-2 trial to determine AGTP efficacy and outcome is currently recruiting patients (NCT02798276). This reparative strategy is safe, avoids the risks associated with ex vivo manipulation, and the preclinical and clinical trials performed to date show cardiac function recovery and reduced necrosis. Confirmation of these data in the AGTP-2 trial could pave the way for the clinical use of this novel modality.
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