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Related Experiment Video

Updated: Feb 13, 2026

Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis
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Neuronal Subtype Generation During Postnatal Olfactory Bulb Neurogenesis.

Alexandra Angelova1, Marie-Catherine Tiveron1, Harold Cremer1

  • 1Aix-Marseille University, CNRS, IBDM, Marseille, France.

Journal of Experimental Neuroscience
|March 8, 2018
PubMed
Summary

Zinc finger proteins Zic1 and Zic2 are newly identified regulators of adult neurogenesis. These factors promote specific neuronal phenotypes in the olfactory bulb, marking a shift from embryonic development.

Keywords:
Neural stem cellsolfactory bulbtranscription factor

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Stem Cell Biology

Background:

  • Neural stem cells in the adult forebrain generate specific neuron types for the olfactory bulb.
  • Postnatal neurogenesis involves a shift in neuronal output compared to embryonic development.

Purpose of the Study:

  • To investigate molecular factors driving stem cell regionalization and the embryonic-to-adult neurogenesis transition.
  • To identify key genes influencing olfactory bulb interneuron production.

Main Methods:

  • High-resolution gene expression analysis across different neural stem cell lineages.
  • Functional studies to assess the impact of specific genes on neuronal fate.

Main Results:

  • Zinc finger proteins Zic1 and Zic2 are induced postnatally in the dorsal olfactory bulb lineage.
  • Zic1 and Zic2 promote GABAergic and calretinin-positive phenotypes.
  • These factors repress dopaminergic neuronal fate.

Conclusions:

  • Zic1 and Zic2 act as master transcription factors in adult neurogenesis.
  • Epigenetic mechanisms and transcription factors are crucial for neuronal fate transitions.
  • Understanding these factors aids in deciphering adult neurogenesis mechanisms.