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Development of Molecularly Targeted Agents and Immunotherapies in Glioblastoma: A Personalized Approach

Niamh Coleman1, Malaka Ameratunga1, Juanita Lopez1

  • 1Drug Development Unit, The Royal Marsden Hospital, London, UK.

Clinical Medicine Insights. Oncology
|March 8, 2018
PubMed

Insights

Precision medicine has advanced solid tumor treatments, but glioblastoma (GBM) remains challenging. Further research is crucial to overcome GBM

Area of Science:

  • Neuro-oncology
  • Genomics
  • Precision Medicine

Background:

  • Precision medicine has revolutionized solid tumor treatment by targeting driver mutations.
  • Glioblastoma (GBM) shows limited response to targeted agents and immunotherapy despite genomic advances.
  • Significant knowledge gaps persist, hindering effective treatment strategies for GBM.

Purpose of the Study:

  • To review therapeutic approaches in glioblastoma.
  • To evaluate the impact and challenges of precision medicine in GBM.
  • To outline strategies for overcoming current therapeutic limitations.

Main Methods:

  • Literature review of glioblastoma therapeutics.
  • Analysis of precision medicine's role and challenges in GBM.
  • Examination of current hypothesis-testing strategies.

Main Results:

  • Targeted agents and immunotherapy have shown limited efficacy in clinical trials for GBM.
  • Tumor heterogeneity and pharmacokinetic-pharmacodynamic issues present major challenges.
  • Novel hypothesis-testing strategies are being developed to address these challenges.

Conclusions:

  • Despite advances in precision medicine for other cancers, GBM treatment remains poor.
  • Addressing tumor heterogeneity and optimizing drug delivery are critical for improving GBM outcomes.
  • Continued research and innovative strategies are urgently needed for effective glioblastoma therapy.
Keywords:
Glioblastomahigh grade gliomaimmunotherapytargeted therapy

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