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Exercise training regulates angiogenic gene expression in white adipose tissue
1Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Journal of Exercise Rehabilitation
|March 8, 2018
Summary
Voluntary wheel running exercise alters angiogenic gene expression in white adipose tissue (WAT) depots. Exercise specifically impacts vascular endothelial growth factor A (VEGFA) and angiopoietin (Ang) expressions in a fat-specific manner.
Area of Science:
- Physiology
- Molecular Biology
- Exercise Science
Background:
- White adipose tissue (WAT) expansion correlates with angiogenesis.
- Exercise-induced lipolysis reduces fat mass, but its effect on WAT angiogenic gene expression is unclear.
Purpose of the Study:
- To investigate the impact of 6 weeks of voluntary wheel running on angiogenic gene expression in various adipose tissues.
- To determine if exercise influences genes like VEGFA, Ang1, Ang2, and PDGF-B in WAT.
Main Methods:
- Male C57BL/6J mice underwent 6 weeks of voluntary wheel running.
- Gene expression analysis (RT-PCR) of specific angiogenic factors and receptors in tibialis anterior, soleus, epididymal WAT, inguinal WAT, and brown adipose tissue post-exercise.
Main Results:
- Skeletal muscles showed increased VEGFA and PDGF-B expression.
- Epididymal WAT exhibited downregulated VEGFA and Flk-1, with upregulated Ang2 and PDGFRβ.
- Inguinal WAT displayed increased VEGF and downregulated Ang1.
- Brown adipose tissue showed no significant changes in the studied genes.
Conclusions:
- Exercise training alters angiogenic gene expression in adipose tissues.
- Voluntary wheel running demonstrates fat depot-specific regulation of VEGFA, Ang1, and Ang2.
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