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Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
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Dependent personality disorder and obsessive-compulsive personality disorder are two separate psychological conditions that influence behavior, relationships, and overall life functioning. Though both involve maladaptive behaviors, their core characteristics and motivations differ significantly.
 Dependent Personality Disorder
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Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
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Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...

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Related Experiment Video

Updated: Jul 27, 2026

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents
08:38

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Published on: September 1, 2011

Impulse control disorders in Parkinson's disease.

Ana Marques1,2, Franck Durif1,2, Pierre-Olivier Fernagut3,4,5,6

  • 1EA 7280, Université Clermont Auvergne, Clermont-Ferrand, France.

Journal of Neural Transmission (Vienna, Austria : 1996)
|March 8, 2018
PubMed
Summary

Impulse control disorders (ICD) are challenging side effects of dopamine replacement therapy (DRT) in Parkinson's disease (PD). Research highlights risk factors and altered brain activity, emphasizing the need for better identification and treatment strategies.

Keywords:
AddictionDopamine agonistImpulse control disordersParkinson’s disease

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Area of Science:

  • Neuroscience
  • Neurology
  • Psychiatry

Background:

  • Impulse control disorders (ICD) are significant side effects of dopamine replacement therapy (DRT) in Parkinson's disease (PD).
  • ICD manifest as behavioral addictions like compulsive gambling, shopping, or eating, primarily linked to dopamine D2/D3 agonists.
  • Managing ICD in PD patients presents a clinical challenge due to limited therapeutic alternatives.

Purpose of the Study:

  • To review the current understanding of impulse control disorders (ICD) in Parkinson's disease (PD) patients undergoing dopamine replacement therapy (DRT).
  • To identify demographic and clinical risk factors associated with ICD development.
  • To explore the neurobiological underpinnings and potential therapeutic avenues for ICD in PD.

Main Methods:

  • Review of clinical studies identifying risk factors for ICD in PD.
  • Analysis of neuroimaging findings in PD patients with ICD, focusing on dopaminergic denervation patterns.
  • Examination of preclinical studies investigating the effects of D2/D3 agonists on behavior relevant to ICD.

Main Results:

  • Identified risk factors include younger age, male gender, prior depression or substance abuse, REM sleep behavior disorder, and higher dyskinesia rates.
  • PD patients with ICD exhibit distinct patterns of ventral striatal dopaminergic denervation and altered activity in reward-related brain regions.
  • Preclinical models show D2/D3 agonists can induce behaviors relevant to ICD, such as risk-taking and perseverative responding.

Conclusions:

  • ICD in PD are complex conditions influenced by genetic predisposition, disease-related neurodegeneration, and DRT.
  • Specific neurobiological alterations in reward pathways are implicated in ICD pathogenesis.
  • Further large-scale longitudinal studies are crucial for identifying at-risk individuals and developing effective treatments.