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Pros and Cons of Intensive Systolic Blood Pressure Lowering

Holly Kramer1,2,3, Richard Cooper4

  • 1Department of Public Health Sciences, Loyola University Chicago, 2160 S. First Avenue, Maywood, IL, 60153, USA. hkramer@lumc.edu.

Current Hypertension Reports
|March 8, 2018
PubMed

Insights

Intensive systolic blood pressure lowering significantly reduces cardiovascular events and mortality in high-risk adults without diabetes. However, this approach increases the risk of adverse events like electrolyte abnormalities and acute kidney injury.

Area of Science:

  • Cardiology
  • Public Health
  • Clinical Trials

Background:

  • The Systolic Blood Pressure Intervention Trial (SPRINT) investigated intensive blood pressure management.
  • High cardiovascular risk in adults without diabetes presents a significant public health challenge.

Purpose of the Study:

  • To evaluate the impact of intensive systolic blood pressure lowering on cardiovascular events and mortality.
  • To assess the associated risks of adverse events with intensive blood pressure management.

Main Methods:

  • Analysis of data from the Systolic Blood Pressure Intervention Trial.
  • Focus on adult participants with high cardiovascular risk and without diabetes.

Main Results:

  • Intensive systolic blood pressure lowering led to significant reductions in cardiovascular events and total mortality.
  • This intensive approach was associated with an increased risk of adverse events, including electrolyte abnormalities and acute kidney injury.

Conclusions:

  • Intensive systolic blood pressure lowering offers substantial benefits for preventing cardiovascular events and mortality in specific high-risk populations.
  • Physicians must carefully weigh the benefits against the increased risks of adverse events when considering this intervention for eligible patients.
Abstract

Keywords:
Acute kidney injuryAdverse eventsBlood pressureCardiovascular mortalityHeart failureIntensive systolic blood pressure loweringMortalitySPRINT trial

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