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Updated: Feb 13, 2026
03:55
A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
Published on: June 27, 2022
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Hydrogen sulfide and autophagy: A double edged sword
Dongdong Wu1, Honggang Wang1, Tieshan Teng1
1School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China.
Pharmacological Research
|March 8, 2018
Summary
Hydrogen sulfide (H₂S) acts as a signaling molecule with complex roles in autophagy. This review details H₂S metabolism and its dual pro- and anti-autophagy signaling pathways, offering insights for therapeutic development.
Area of Science:
- Biochemistry
- Cell Biology
- Physiology
Background:
- Hydrogen sulfide (H₂S) is recognized as the third gaseous signaling molecule.
- H₂S influences numerous physiological and pathological processes.
- Its role in autophagy remains a subject of debate, with conflicting evidence.
Purpose of the Study:
- To review mammalian H₂S metabolism.
- To discuss signaling pathways involved in H₂S-mediated autophagy.
- To explore the therapeutic potential of H₂S in human diseases by modulating autophagy.
Main Methods:
- Literature review of existing studies on H₂S and autophagy.
- Analysis of signaling pathways implicated in H₂S effects on autophagy.
- Summary of H₂S metabolism in mammals.
Main Results:
- H₂S exhibits both pro-autophagy and anti-autophagy effects.
- Pro-autophagy pathways include PI3K/Akt/mTOR, AMPK/mTOR, LKB1/STRAD/MO25, and miR-30c.
- Anti-autophagy pathways involve SR-A, PI3K/SGK1/GSK3β, PI3K/AKT/mTOR, Nrf2-ROS-AMPK, AMPK/mTOR, and JNK1.
Conclusions:
- H₂S has a dual role in autophagy, mediated by distinct signaling pathways.
- Understanding these pathways is crucial for developing novel H₂S-releasing drugs.
- Targeting H₂S-mediated autophagy holds promise for treating human diseases.
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