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Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

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IGF Binding Protein-5 Induces Cell Senescence

Fumihiro Sanada1, Yoshiaki Taniyama1,2, Jun Muratsu1,2

  • 1Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Frontiers in Endocrinology
|March 9, 2018
PubMed

Insights

Insulin-like growth factor-binding protein-5 (IGFBP-5) drives cellular senescence and inflammation. This protein is upregulated during aging, impacting organ function and potentially linking to age-related hyper-coagulation.

Area of Science:

  • Gerontology
  • Cell Biology
  • Molecular Biology

Background:

  • Cellular senescence is a key driver of organismal aging and organ dysfunction.
  • Senescence involves irreversible growth arrest, often triggered by telomere shortening or stress.
  • Senescent cells are linked to age-related inflammation and hyper-coagulation.

Purpose of the Study:

  • To review the role of Insulin-like Growth Factor-binding Protein-5 (IGFBP-5) in cellular senescence and inflammation.
  • To highlight the upregulation of IGFBP-5 during senescence, mediated by the tumor suppressor p53.
  • To explore the implications of IGFBP-5 in age-related conditions.

Main Methods:

  • Review of existing literature on cellular senescence and IGFBP-5.
  • Analysis of studies demonstrating IGFBP-5 upregulation in various senescence models.
  • Examination of the link between IGFBP-5, inflammation, and coagulation.

Main Results:

  • IGFBP-5 is upregulated during cellular senescence, induced by p53.
  • This upregulation mediates premature senescence in fibroblasts and endothelial cells (ECs).
  • IGFBP-5 is implicated in age-related inflammation and hyper-coagulation.

Conclusions:

  • IGFBP-5 plays a critical role in regulating cellular senescence and inflammation.
  • The protein's involvement in senescence is independent of IGF-I and IGF-II.
  • IGFBP-5 represents a potential therapeutic target for age-related diseases.
Keywords:
IGF binding protein-5age-related diseasecell senescencecoagulation systeminflammation

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