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Newly developed anti-angiogenic therapy in non-small cell lung cancer

Jingjing Qu1, Yongchang Zhang1, Xue Chen1

  • 1Department of Lung Cancer and Gastrointestinal Oncology Medicine, Hunan Cancer Hospital, Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, 410013, China.

Oncotarget
|March 9, 2018
PubMed

Insights

Anti-angiogenic therapies show limited clinical benefit in advanced non-small cell lung cancer (NSCLC). This review examines their efficacy alongside chemotherapy, targeted therapy, and immunotherapy to optimize their use in NSCLC treatment.

Area of Science:

  • Oncology
  • Cancer Research
  • Translational Medicine

Background:

  • Angiogenesis is crucial for non-small cell lung cancer (NSCLC) metastasis.
  • Vascular endothelial growth factor (VEGF) is a key driver in advanced NSCLC.
  • Anti-angiogenic therapies offer potential but limited clinical benefit in NSCLC.

Purpose of the Study:

  • To review the efficacy of anti-angiogenic molecules in advanced NSCLC.
  • To evaluate their use in combination with chemotherapy, targeted therapy, and immunotherapy.
  • To guide optimal application of angiogenesis therapy in advanced NSCLC.

Main Methods:

  • Literature review of clinical data.
  • Analysis of first-line and second-line treatment outcomes.
  • Examination of combination therapies including epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and immunotherapy.

Main Results:

  • Anti-angiogenic therapies demonstrate variable and often limited efficacy in advanced NSCLC.
  • Combination strategies show potential but require further validation.
  • Clinical benefit is often quantitatively restricted.

Conclusions:

  • Optimizing the use of anti-angiogenic therapy in advanced NSCLC is critical.
  • Further research is needed to enhance the clinical benefit of these agents.
  • Understanding treatment combinations is key to improving patient outcomes.
Keywords:
NSCLCangiogenesiscombined with chemotherapyimmunotherapytyrosine kinase inhibitor

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